FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tllEGFP
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General Information
Symbol
Dmel\tllEGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0241875
Feature type
allele
Associated gene
Dmel\tll
Associated Insertion(s)
Carried in Construct
PBac{tll-EGFP.S}
Also Known As
tll::GFP, tll-GFP
Key Links
Transgenic product class
genomic_DNA
(Venken et al., 2009)
wild_type
(Venken et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Venken et al., 2009)
wild_type
(Venken et al., 2009)
Mutagen
in vitro construct
(Venken et al., 2009, Venken et al., 2009)
Progenitor genotype
tlltCH322-83J21
(Venken et al., 2009)
Carried in construct
PBac{tll-EGFP.S}
Cytology
Description

A EGFP reporter tag is inserted in-frame at the 3' end of the tll open-reading frame, replacing the stop codon and creating a gene encoding a C-terminal protein fusion.

(Venken et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
tll
Encoded product / tool
tll
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter or direct label
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage 16
      type I neuroblast of embryonic brain
      (Curt et al., 2019)
      type II neuroblast of embryonic brain
      (Curt et al., 2019)
      third instar larval stage
      type II neuroblast
      (Rives-Quinto et al., 2020)
      type I neuroblast

      Comment: low level

      (Rives-Quinto et al., 2020)
      Additional Information
      Statement
      Reference

      GFP-tagged tll protein is detected in type II neuroblasts but not in immature or mature secondary neuroblasts. It is also detected in type I neuroblasts in the brain and in the ventral nerve cord, but at a significantly lower level than in type II neuroblasts

      (Rives-Quinto et al., 2020)

      tll reporter is most if not all type I neuroblasts in the B1 region of the embryonic brain. The tll reporter is expressed in all three type II neuroblast clusters

      (Curt et al., 2019)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tllEGFP
      tllT:Avic\GFP-EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (10)