FlyBase Allele Report: Dmel\Kap-α3[17-76]

General Information

Symbol

Dmel\Kap-α3^17-76

Species

D. melanogaster

Name

FlyBase ID

FBal0241956

Feature type

allele

Associated gene

Dmel\Kap-α3

Associated Insertion(s)

Carried in Construct

Also Known As

impα3^17-76

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Ferguson et al., 2009)

abnormal phototaxis | somatic clone

(Ting et al., 2007)

Phenotype Manifest In

photoreceptor cell R7

(Ferguson et al., 2009)

photoreceptor cell R7 | somatic clone

(Ting et al., 2007)

Detailed Description

Statement

Reference

Kap-α3^17-76 axonal somatic clones exhibit a tiling defect (where they invade adjacent columns in the target region) in 33% of cases.

(Ferguson et al., 2009)

A significant proportion of Kap-α3^17-76 mosaic flies exhibit mutant R7 photoreceptor cells and do not phototax to visible light.

Kap-α3^17-76 MARCM clone R7 axons terminate correctly in the M6 layer, although a significant proportion extend laterally into columns occupied by neighboring wildtype R7s.

(Ting et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Kap-α3^17-76 has abnormal neuroanatomy phenotype, enhanceable by tutl⁰¹⁰⁸⁵/tutl[+]

(Ferguson et al., 2009)

Kap-α3^17-76 has abnormal neuroanatomy phenotype, enhanceable by tutl^RNAi.400.UAS/Scer\GAL4^GMR.long

(Ferguson et al., 2009)

Enhancer of

Statement

Reference

Kap-α3^17-76 is an enhancer of abnormal neuroanatomy phenotype of tutl⁰¹⁰⁸⁵

(Ferguson et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

Kap-α3^17-76 has photoreceptor cell R7 phenotype, enhanceable by tutl⁰¹⁰⁸⁵/tutl[+]

(Ferguson et al., 2009)

Kap-α3^17-76 has photoreceptor cell R7 phenotype, enhanceable by tutl^RNAi.400.UAS/Scer\GAL4^GMR.long

(Ferguson et al., 2009)

Enhancer of

Statement

Reference

Kap-α3^17-76 is an enhancer of photoreceptor cell R7 phenotype of tutl⁰¹⁰⁸⁵

(Ferguson et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

A tutl⁰¹⁰⁸⁵ heterozygous background enhances the frequency of tiling defects in Kap-α3^17-76 axonal somatic clones.

A Kap-α3^17-76 heterozygous background enhances the frequency of tiling defects in tutl⁰¹⁰⁸⁵ axonal somatic clones.

Reducing the level of tutl through tutl^{dsRNA.400.Scer\UAS} somatic clones in the eye (under the control of flp and Scer\GAL4^GMR.long) enhances the tendency of Kap-α3^17-76 mutant axons to invade neighboring columns.

(Ferguson et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Kap-α3^17-76

impα3^17-76

(Ferguson et al., 2009, Ting et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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