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General Information
Symbol
Dmel\mid1a5
Species
D. melanogaster
Name
FlyBase ID
FBal0241992
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C5464061T

Amino acid change:

Q144term | mid-PA; Q144term | mid-PB

Reported amino acid change:

?144term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: ?144term.

Mutation truncates the protein just prior to the T-box domain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Somatic double mutant clones of mid1a5 and Df(2L)H15-x4 in the leg imaginal disc cause the autonomous transformation of the wg-dependent peg-shaped row 1/8 bristles into lateral or dorsal rapier-like bristles. Similar cell-autonomous transformations are observed in the second leg tibia, in which the ventral apical bristle is lost in double mutant clones that span the distal tibia. In most of the double mutant clones, a large bristle similar to the dorsally located pre-apical bristle develop in place of the apical bristle. The apical bristle associated cluster of peg-shaped spur bristles are autonomously transformed to dorsal-like rapier-shaped bristles in mid1a5-Df(2L)H15-x4 clones. The sex combs and transverse rows of the first leg are also deleted in mid1a5-Df(2L)H15-x4 clones. Other ventral structures are either lost or disorganised within mid1a5-Df(2L)H15-x4 clones.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
References (7)