FB2026_02 , released June 18, 2026
Allele: Dmel\pcm3
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General Information
Symbol
Dmel\pcm3
Species
D. melanogaster
Name
FlyBase ID
FBal0242030
Feature type
allele
Associated gene
Dmel\pcm
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Lin et al., 2008)
Mutagen
P-element activity
(Grima et al., 2008)
Progenitor genotype
P{EP}EP1526
(Grima et al., 2008)
Cytology
Description

Imprecise excision of the P{EP}EP1526 insertion, resulting in a deletion that is predicted to produce a truncated pcm protein of 1461 amino acid residues.

(Grima et al., 2008)

Comprises a deletion of 1522bp, resulting in a frame-shift mutation. Mutant protein is a C-terminal truncation of 197 aa relative to wildtype plus an extra 46 aa encoded from intergenic sequences. The 3' UTR is also deleted.

(Zabolotskaya et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:19,485,300..19,486,692 [-]
Comment:

Approximate endpoints of a deletion resulting from the imprecise excision of P{EP}EP1526. Reported as producing a truncated pcm protein of 1461 aa.

(Grima et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      pcm3 is cold sensitive.

      Wounded pcm5 homozygous flies have reduced survival rates compared to control flies at both 19[o]C and 25[o]C. The clotting process in mutants follows a similar time course to that of controls.

      (Grima et al., 2008)

      pcm3 homozygous mutant females lay fewer eggs than controls and many egg chambers degenerate around stage 9.

      (Lin et al., 2008)

      pcm3 males are compromised in their fertility, producing approximately 60% of the progeny of control males at 25[o]C.

      Testes from pcm3 males are slightly shorter and thinner compared to control males.

      pcm3 males produce fewer sperm (68% of wildtype).

      (Zabolotskaya et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pcm3
      (Grima et al., 2008, Lin et al., 2008, Lin et al., 2008, Zabolotskaya et al., 2008)
      Name Synonyms
      pacman3
      (Lin et al., 2008)
      Secondary FlyBase IDs
        References (4)