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General Information
Symbol
Dmel\HPS4W515X
Species
D. melanogaster
Name
FlyBase ID
FBal0242041
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dHPS4W515X
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G17688966A

Amino acid change:

W539term | HPS4-PA; W515term | HPS4-PB

Reported amino acid change:

W515term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: W515term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant flies show a significant decrease in ommochrome pigment levels and a modest reduction in drosopterin pigment levels compared to wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

HPS4W515X is an enhancer of abnormal eye color phenotype of wIR.GMR

Phenotype Manifest In
Enhancer of
Statement
Reference

HPS4W515X is an enhancer of eye phenotype of wIR.GMR

Additional Comments
Genetic Interactions
Statement
Reference

The reduction in ommochrome pigment levels that is seen in ltd1 flies is not affected by HPS4W515X.

The reduction in drosopterin pigment levels that is seen in car1 and p1 flies is not affected by HPS4W515X.

The reduction in drosopterin pigment levels seen in flies carrying wdsRNA.GMR is enhanced manyfold if they are also mutant for HPS4W515X.

The lighter colour of wIR.GMR eyes is enhanced when eyes are also made homozygous mutant for HPS4W515X (using the "eyFLP/FRT" system).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)