FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HPS4W515X
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General Information
Symbol
Dmel\HPS4W515X
Species
D. melanogaster
Name
FlyBase ID
FBal0242041
Feature type
allele
Associated gene
Dmel\HPS4
Associated Insertion(s)
Carried in Construct
Also Known As
dHPS4W515X
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lee et al., 2009)
Progenitor genotype
Cytology
Description

Amino acid replacement: W515term.

(Lee et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:17,688,966..17,688,966 [+]
Nucleotide change:

G17688966A

Amino acid change:

W539term | HPS4-PA; W515term | HPS4-PB

Reported amino acid change:

W515term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Lee et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant flies show a significant decrease in ommochrome pigment levels and a modest reduction in drosopterin pigment levels compared to wild type.

      (Harris et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      HPS4W515X is an enhancer of abnormal eye color phenotype of wRNAi.GMR

      (Lee et al., 2009)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      HPS4W515X is an enhancer of eye phenotype of wRNAi.GMR

      (Lee et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The reduction in ommochrome pigment levels that is seen in ltd1 flies is not affected by HPS4W515X.

      The reduction in drosopterin pigment levels that is seen in car1 and p1 flies is not affected by HPS4W515X.

      The reduction in drosopterin pigment levels seen in flies carrying wdsRNA.GMR is enhanced manyfold if they are also mutant for HPS4W515X.

      (Harris et al., 2011)

      The lighter colour of wIR.GMR eyes is enhanced when eyes are also made homozygous mutant for HPS4W515X (using the "eyFLP/FRT" system).

      (Lee et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HPS4W515X
      dHPS4W515X
      (Harris et al., 2011, Lee et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)