FlyBase Allele Report: Dmel\PK1-R[JF02690]

General Information

Symbol

Dmel\PK1-R^JF02690

Species

D. melanogaster

Name

FlyBase ID

FBal0242278

Feature type

allele

Associated gene

Dmel\PK1-R

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02690}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02690}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02690

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of obesity

CEA

(Alfa et al., 2015)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased rate of movement | adult stage, with Scer\GAL4^elav.PU

(Yu et al., 2016)

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of PK1-R^JF02690 under the control of Scer\GAL4^elav-C155 does not affect the expected increase in food consumption induced by dietary amino acids, as observed in controls.

(Yang et al., 2018)

Expression of PK1-R^JF02690 under the control of Scer\GAL4^elav.PU in adult females significantly decreases locomotor activity in fed conditions, compared to controls; like controls, locomotor activity is significantly increased under starvation conditions.

(Yu et al., 2016)

PK1-R knock-down in Insulin Producing Cells (Scer\GAL4^Ilp2.215-1-mediated expression of PK1-R^JF02690) results in increased adiposity.

(Alfa et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27539

y¹ v¹; P{TRiP.JF02690}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG9918^JF02690

PK1-R^JF02690

Pk1r^JF02690

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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