FlyBase Allele Report: Dmel\Pp2A-29B[JF03316]

General Information

Symbol

Dmel\Pp2A-29B^JF03316

Species

D. melanogaster

Name

FlyBase ID

FBal0242492

Feature type

allele

Associated gene

Dmel\Pp2A-29B

Associated Insertion(s)

Carried in Construct

P{TRiP.JF03316}

Also Known As

JF03316

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF03316}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF03316

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by Rbf^HMS03004

(Parkhitko et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^RapGAP1-OK6

(Gao et al., 2024)

visible, with Scer\GAL4^bbg-C96

(Kwon et al., 2013)

Phenotype Manifest In

neuromuscular junction, with Scer\GAL4^elav-C155

(Bulat et al., 2014)

NMJ bouton | larval stage, with Scer\GAL4^RapGAP1-OK6

(Gao et al., 2024)

synapse, with Scer\GAL4^elav-C155

(Bulat et al., 2014)

wing margin, with Scer\GAL4^bbg-C96

(Kwon et al., 2013)

Detailed Description

Statement

Reference

Expression of Pp2A-29B^JF03316 in the fat body under the control of Scer\GAL4^DcG results in significant hyperglycaemia.

(Ugrankar et al., 2015)

Presynaptic expression of Pp2A-29B^JF03316 under the control of Scer\GAL4^elav-C155 causes synaptic retractions in just under 50% of synapses.

(Bulat et al., 2014)

Expression of Pp2A-29B^JF03316 under the control of Scer\GAL4^bbg-C96 results in a high penetrance of wing nicking.

(Kwon et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Pp2A-29B^JF03316, Scer\GAL4^Myo31DF.PU is an enhancer of increased occurrence of cell division | adult stage phenotype of PXo^HMS01023, Scer\GAL4^Myo31DF.PU

(Xu et al., 2023)

Pp2A-29B^JF03316, Scer\GAL4^bbg-C96 is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

Suppressor of

Statement

Reference

Pp2A-29B^JF03316, Scer\GAL4^esg.PU is a suppressor of increased occurrence of cell division | adult stage phenotype of PXo^HMS01023, Scer\GAL4^esg.PU

(Xu et al., 2023)

Phenotype Manifest In

Enhancer of

Statement

Reference

Pp2A-29B^JF03316, Scer\GAL4^Myo31DF.PU is an enhancer of adult midgut phenotype of PXo^HMS01023, Scer\GAL4^Myo31DF.PU

(Xu et al., 2023)

Pp2A-29B^JF03316, Scer\GAL4^bbg-C96 is an enhancer of wing margin phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

Suppressor of

Statement

Reference

Pp2A-29B^JF03316, Scer\GAL4^esg.PU is a suppressor of adult midgut phenotype of PXo^HMS01023, Scer\GAL4^esg.PU

(Xu et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

The wing nicking phenotype caused by expression of dom^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^bbg-C96 is enhanced if the flies are also co-expressing Pp2A-29B^JF03316.

(Kwon et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

29384

y¹ v¹; P{TRiP.JF03316}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pp2A-29B^JF03316

pP2A-29B^JF03316

(Neisch et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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