FlyBase Allele Report: Dmel\Dad[UASp.cJa]

General Information

Symbol

Dmel\Dad^UASp.cJa

Species

D. melanogaster

Name

FlyBase ID

FBal0242616

Feature type

allele

Associated gene

Dmel\Dad

Associated Insertion(s)

Carried in Construct

P{UASp-Dad.J}

Also Known As

uasp-dad, P{uasp-dad}

Key Links

Transgenic product class

wild_type

(Jiang et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Jiang et al., 2008)

Mutagen

in vitro construct

(Jiang et al., 2008)

Progenitor genotype

Carried in construct

P{UASp-Dad.J}

Cytology

Description

UASp regulatory sequences drive expression of Dad.

(Jiang et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Dad

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

female germline stem cell, with Scer\GAL4^{VP16.nanos.UTR}

(Jiang et al., 2008)

Detailed Description

Statement

Reference

Expression of Dad^{Scer\UAS.P\T.cJa} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} in females results in the loss of germ cells, including the germline stem cells.

(Jiang et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}/Dad^UASp.cJa is a suppressor of hyperplasia | adult stage phenotype of fu⁴¹

(Xia et al., 2010)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Dad^UASp.cJa, Scer\GAL4^{VP16.nanos.UTR} has female germline stem cell phenotype, non-suppressible by Ote^nanos.PJ

(Jiang et al., 2008)

Suppressor of

Statement

Reference

Dad^UASp.cJa, Scer\GAL4^{VP16.nanos.UTR} is a suppressor of female germline stem cell | increased number phenotype of Scer\GAL4^{VP16.nanos.UTR}, lili^UASp.cDa

(Dolezal et al., 2015)

Scer\GAL4^{VP16.nanos.UTR}/Dad^UASp.cJa is a suppressor of ovary phenotype of fu⁴¹

(Xia et al., 2010)

Scer\GAL4^{VP16.nanos.UTR}/Dad^UASp.cJa is a suppressor of germarium phenotype of fu⁴¹

(Xia et al., 2010)

Scer\GAL4^{VP16.nanos.UTR}/Dad^UASp.cJa is a suppressor of female germline cell | increased number phenotype of fu⁴¹

(Xia et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Dad^{Scer\UAS.P\T.cJa} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} suppresses the increase in spectrosome-containing GSC-like cells seen in fu⁴¹ mutant germaria.

(Xia et al., 2010)

Co-expression Ote^nos.PJ and of Dad^{Scer\UAS.P\T.cJa} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} results in the complete loss of germline stem cells in the ovary.

(Jiang et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Dad^{Scer\UAS.P\T.cJa}

Dad^UASp.cJa

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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