FB2026_02 , released June 18, 2026
Allele: Dmel\Br140S781
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General Information
Symbol
Dmel\Br140S781
Species
D. melanogaster
Name
FlyBase ID
FBal0242945
Feature type
allele
Associated gene
Dmel\Br140
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Berger et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid numbering based on PA isoform.

(Berger et al., 2008)

Amino acid replacement: W325term.

(Berger et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:7,276,909..7,276,909 [-]
Nucleotide change:

G7276909A

Amino acid change:

W325term | Br140-PA; W325term | Br140-PB

Reported amino acid change:

W325term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase base on reported amino acid change.

(Berger et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Photoreceptor axons do not project correctly in the optic lobe of Br140S781 eye-brain complexes in third instar larvae, while the photoreceptor cells themselves are appropriately specified.

      Dorsal Ecol\lacZbi.T:Btau\MAPT-marked axons project aberrantly to the ventral region of the optic lobe in Br140S781 whole-eye Scer\FLP1ey.PN clones in third instar larvae. (Ventral axons mistargeting to dorsal regions is not seen.)

      (Berger et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Br140S781 is rescued by Br140ey.PB

      (Berger et al., 2008)
      Comments

      Expression of Br140ey.PB restores normal targeting of dorsal axons in Br140S781 eye discs.

      (Berger et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Br140S781
      (Kang et al., 2017, Berger et al., 2008)
      S781
      (Berger et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)