FB2026_02 , released June 18, 2026
Allele: Dmel\enokK1293
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General Information
Symbol
Dmel\enokK1293
Species
D. melanogaster
Name
FlyBase ID
FBal0242957
Feature type
allele
Associated gene
Dmel\enok
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Berger et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid numbering based on PA isoform.

(Berger et al., 2008)

Amino acid replacement: R365term.

(Berger et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:24,101,092..24,101,092 [+]
Nucleotide change:

A24101092T

Amino acid change:

R365term | enok-PA; R365term | enok-PB

Reported amino acid change:

R365term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Berger et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Marked enokK1293 mutant female germline stem cells (GSCs) are present only 2 days after clone induction (ACI), but absent at 21 days ACI. Control clones are present at 21 days ACI. The mutant cells differentiate into marked mutant cysts. The cells in the mutant clones do not display signs of apoptosis.

      (Xin et al., 2013)

      Photoreceptor axons do not project correctly in the optic lobe of enokK1293 eye-brain complexes in third instar larvae, while the photoreceptor cells themselves are appropriately specified.

      Dorsal Ecol\lacZbi.T:Btau\MAPT-marked axons project aberrantly to the ventral region of the optic lobe in enokK1293 whole-eye Scer\FLP1ey.PN clones in third instar larvae. (Ventral axons mistargeting to dorsal regions is not seen.)

      enokK1293 eyes are sometimes reduced in size.

      (Berger et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      enokK1293/enok[+] is an enhancer of female germline stem cell | progressive phenotype of Scer\GAL4VP16.nanos.UTR, bru1UASp.cFa

      (Xin et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygosity for enokK1293 exacerbates the female germline stem cell loss elicited by Scer\GAL4nos.UTR.T:Hsim\VP16>aretScer\UAS.P\T.cFa overexpression.

      (Xin et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      enokK1293 is rescued by enokey.PB

      (Berger et al., 2008)
      Comments

      Expression of enokey.PB restores normal targeting of dorsal axons in enokK1293 eye discs.

      (Berger et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      K1293
      (Berger et al., 2008)
      enokK1293
      (Xin et al., 2013, Berger et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)