FlyBase Allele Report: Dmel\Wnk[G1286]

General Information

Symbol

Dmel\Wnk^G1286

Species

D. melanogaster

Name

FlyBase ID

FBal0242968

Feature type

allele

Associated gene

Dmel\Wnk

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Berger et al., 2008)

Progenitor genotype

Cytology

Description

Amino acid numbering based on PA isoform.

(Berger et al., 2008)

Amino acid replacement: S529F.

(Berger et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:21,551,815..21,551,815 [-]

Nucleotide change:

C21551815T

Amino acid change:

S556F | Wnk-PL; S556F | Wnk-PM; S556F | Wnk-PN; S358F | Wnk-PO

Reported amino acid change:

S529F

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Berger et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | progressive | somatic clone

(Izadifar et al., 2021)

abnormal neuroanatomy | somatic clone | third instar larval stage

(Berger et al., 2008)

Phenotype Manifest In

adult mechanosensory neuron | somatic clone

(Izadifar et al., 2021)

axon | adult stage | somatic clone

(Izadifar et al., 2021)

mechanosensory neuron of posterior dorsocentral bristle | adult stage | somatic clone

(Izadifar et al., 2021)

mechanosensory neuron of posterior scutellar bristle | adult stage | somatic clone

(Izadifar et al., 2021)

Detailed Description

Statement

Reference

Photoreceptor axons do not project correctly in the optic lobe of Wnk^G1286 eye-brain complexes in third instar larvae, while the photoreceptor cells themselves are appropriately specified.

(Berger et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Wnk^G1286 has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, suppressible by Scer\GAL4^elav-C155/axed^HMJ22228

(Izadifar et al., 2021)

Wnk^G1286 has abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype, suppressible by Scer\GAL4^elav-C155/Nmnat^UAS.Tag:HA

(Izadifar et al., 2021)

Phenotype Manifest In

Suppressed by

Statement

Reference

Wnk^G1286 has axon | somatic clone | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/axed^HMJ22228

(Izadifar et al., 2021)

Wnk^G1286 has adult mechanosensory neuron | somatic clone phenotype, suppressible by Scer\GAL4^elav-C155/axed^HMJ22228

(Izadifar et al., 2021)

Wnk^G1286 has axon | somatic clone | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Nmnat^UAS.Tag:HA

(Izadifar et al., 2021)

Wnk^G1286 has adult mechanosensory neuron | somatic clone phenotype, suppressible by Scer\GAL4^elav-C155/Nmnat^UAS.Tag:HA

(Izadifar et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

G1286

(Berger et al., 2008)

Wnk^G1286

(Izadifar et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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