FB2026_02 , released June 18, 2026
Allele: Dmel\HisCl1+t14.3
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General Information
Symbol
Dmel\HisCl1+t14.3
Species
D. melanogaster
Name
FlyBase ID
FBal0243131
Feature type
allele
Associated gene
Dmel\HisCl1
Associated Insertion(s)
Carried in Construct
P{HisCl1+t14.3}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Hong et al., 2006)
wild_type
(Hong et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Hong et al., 2006)
wild_type
(Hong et al., 2006)
Mutagen
in vitro construct
(Hong et al., 2006)
Progenitor genotype
Carried in construct
P{HisCl1+t14.3}
Cytology
Description

A 14.3 kb ClaI BamHI genomic fragment containing the entire coding sequence of HisCl1.

(Hong et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
HisCl1
HisCl1_14.3kb
Encoded product / tool
HisCl1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3R:11,777,329..11,791,688 [+]
Linked to:
ClaI-BamHI restriction fragment
Comment:

Reported as a 10.3kb genomic fragment containing HisCl1 and about 10kb of upstream and 2kb of downstream sequences. Position of rescue fragment on reference sequence inferred by FlyBase curator.

(Hong et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      ort+t13.3/HisCl1+t14.3 is a suppressor of abnormal thermotaxis | recessive phenotype of HisCl1134, ort1

      (Hong et al., 2006)

      ort+t13.3/HisCl1+t14.3 is a suppressor of paralytic | recessive | heat sensitive phenotype of HisCl1134, ort1

      (Hong et al., 2006)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      HisCl1134, ort1 homozygous adults have a reduced tolerance for hight temperatures and slower recovery following heat shock. They also have a significantly increased death rate after 6 days at 4'C compared to wild-type, but they recover more quickly from a cold induced coma. These phenotypes are largely rescued by HisCl1+t14.3; ort+t13.3.

      (Hong et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      HisCl1+t14.3
      Name Synonyms
      Secondary FlyBase IDs
        References (2)