FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SMC1UAS.Tag:HA
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General Information
Symbol
Dmel\SMC1UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0243251
Feature type
allele
Associated gene
Dmel\SMC1
Associated Insertion(s)
Carried in Construct
P{UAS-SMC1.HA}
Key Links
Transgenic product class
wild_type
(Schuldiner et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Schuldiner et al., 2008)
Mutagen
in vitro construct
(Schuldiner et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-SMC1.HA}
Cytology
Description

UAS regulatory sequences drive expression of the SMC1 coding region which is tagged with a Tag:HA epitope.

(Schuldiner et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
SMC1
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of SMC1Scer\UAS.T:Ivir\HA1 under the control of either Scer\GAL4ey-OK107 or Scer\GAL4Tab2-201Y does not result in any detectable gain of function phenotype in the mushroom body.

      (Schuldiner et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4ey-OK107/SMC1UAS.Tag:HA rescues SMC1LL01162

      (Schuldiner et al., 2008)
      Partially rescues

      Scer\GAL4Tab2-201Y/SMC1UAS.Tag:HA partially rescues SMC1LL01162

      (Schuldiner et al., 2008)

      Scer\GAL4GH146/SMC1UAS.Tag:HA partially rescues SMC1LL01162

      (Schuldiner et al., 2008)
      Comments

      Expression of SMC1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ey-OK107 fully rescues both the neuroblast proliferation and the axon pruning defects of SMC1LL01162 neuroblast clones in the mushroom body.

      Expression of SMC1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Tab2-201Y does not rescue the neuroblast-proliferation defect of SMC1LL01162 neuroblast clones in the mushroom body, although the axon pruning defects of the SMC1LL01162 clones are rescued.

      Expression of SMC1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GH146 does not rescue the reduction of cell number in all three types of projection neuron (PN) neuroblast clones. However, there is a significant rescue of dendrite targeting defects in all three PN lineages; adPNs always target to VA3, lPNs always target to DA1 and vPNs are either rescued to a wild-type innervation pattern or show minor dendritic misrouting to the subesophageal ganglion.

      (Schuldiner et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SMC1Scer\UAS.T:Ivir\HA1
      SMC1UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)