FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Taf6hs.Tag:FLAG
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General Information
Symbol
Dmel\Taf6hs.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0243571
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

An Hsp70 promoter drives expression of Taf6 which is tagged at the N-terminal end with Tag:FLAG.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Taf6XS-922 homozygotes rescued to adulthood by expression of Taf6hs.T:Zzzz\FLAG have an external rough eye phenotype. The ommatidia have an abnormal number of photoreceptors in many cases, either missing an inner or outer photoreceptor or having an extra inner or outer photoreceptor. The mutant rhabdomeres are larger than normal in the mutant animals. The mutant adults have a notched wing phenotype.

Taf6XS-922/Taf62 animals rescued to adulthood by expression of Taf6hs.T:Zzzz\FLAG have notched wing and rough eye phenotypes, which are less severe if the animals are heat shocked during adulthood to express Taf6hs.T:Zzzz\FLAG.

Taf63 homozygous third instar larvae and adults which have been rescued by expression of Taf6hs.T:Zzzz\FLAG contain dark black masses of cells resembling melanotic pseudotumours.

Taf6XS-922/Taf62 males rescued to adulthood by expression of Taf6hs.T:Zzzz\FLAG (including heat shock during the adult stage) have postmeiotic stages including mature spermatids in the testis, but they are less abundant than in wild type. Taf6XS-922/Taf62 males rescued to adulthood by expression of Taf6hs.T:Zzzz\FLAG with no heat shock during the adult stage have a more severe phenotype; proliferation of stem cells to primary spermatocytes is normal, but the primary spermatocytes occupy an abnormally large portion of the testis and degenerate without initiating meiotic chromosome condensation.

Taf6XS-922 homozygous males rescued to adulthood by expression of Taf6hs.T:Zzzz\FLAG have needle-like structures in the spermatocytes.

Taf6unspecified females rescued to adulthood by expression of Taf6hs.T:Zzzz\FLAG are sterile and lay eggs with polarity defects ranging from strongly dorsalised to strongly ventralised (as determined by the phenotype of the dorsal appendages). Some of the eggs are small, have thin egg shells and have a mixture of dorsal and ventral characteristics.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Taf6hs.T:Zzzz\FLAG
Taf6hs.Tag:FLAG
Name Synonyms
Secondary FlyBase IDs
    References (1)