FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\jubRNAi.C.UAS.22.5
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General Information
Symbol
Dmel\jubRNAi.C.UAS.22.5
Species
D. melanogaster
Name
FlyBase ID
FBal0243586
Feature type
allele
Associated gene
Dmel\jub
Associated Insertion(s)
Carried in Construct
P{UAS-jub.RNAi.22.5}
Key Links
Transgenic product class
RNAi_reagent
(Das Thakur et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Das Thakur et al., 2010)
Mutagen
in vitro construct
(Das Thakur et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-jub.RNAi.22.5}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of a 445 nt fragment of jub starting at 226 nt before the start codon.

(Das Thakur et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
jub
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4Act5C.PI-driven expression of jubdsRNA.C.Scer\UAS.22.5 results in pharate lethality.

      Scer\GAL4Bx-MS1096-driven jubdsRNA.C.Scer\UAS.22.5 expression in the wing decreases wing size as compared to wild-type controls. The small-wing phenotype is due to decreased cell number, not cell size, and wing patterning appeared unaffected.

      Scer\GAL4GMR.PF-driven jubdsRNA.C.Scer\UAS.22.5 expression in the pupal eye epithelium results in reduction in the number of interommatidial cells without any disruption to ommatidial patterning.

      (Das Thakur et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Overexpression of Hsap\LIMD1Scer\UAS.T:Ivir\HA rescues the wing phenotypes resulting from the Scer\GAL4Bx-MS1096-driven expression of jubdsRNA.C.Scer\UAS.22.5

      (Das Thakur et al., 2010)
      Complementation and Rescue Data
      Partially rescued by

      jubRNAi.C.UAS.22.5 is partially rescued by jubUAS.mCherry/Scer\GAL4Bx-MS1096

      (Das Thakur et al., 2010)

      jubRNAi.C.UAS.22.5 is partially rescued by jubUAS.mCherry/Scer\GAL4GMR.PF

      (Das Thakur et al., 2010)
      Comments

      Co-expression of jubScer\UAS.T:Disc\RFP-mCherry rescues partially rescues the wing phenotypes resulting from the Scer\GAL4Bx-MS1096-driven expression of jubdsRNA.C.Scer\UAS.22.5

      Co-expression of jubScer\UAS.T:Disc\RFP-mCherry rescues partially rescues the eye phenotypes resulting from the Scer\GAL4GMR.PF-driven expression of jubdsRNA.C.Scer\UAS.22.5.

      (Das Thakur et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      jubRNAi.C.UAS.22.5
      jubdsRNA.C.Scer\UAS.22.5
      jubdsRNA.C.UAS.22.5
      Name Synonyms
      Secondary FlyBase IDs
        References (4)