FlyBase Allele Report: Dmel\Rdl[RNAi.4-5.UAS]

General Information

Symbol

Dmel\Rdl^RNAi.4-5.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0243636

Feature type

allele

Associated gene

Dmel\Rdl

Associated Insertion(s)

Carried in Construct

P{UAS-Rdl.RNAi.4-5}

Also Known As

Rdli4-5

Key Links

Transgenic product class

RNAi_reagent

(Liu et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Liu et al., 2007)

Mutagen

in vitro construct

(Liu et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-Rdl.RNAi.4-5}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat of a fragment encoding Rdl exons 4 and 5 (one copy of the repeat is derived from genomic sequence, and one copy is from cDNA sequence).

(Liu et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Rdl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning, with Scer\GAL4^c747

(Liu et al., 2009, Liu et al., 2007)

Phenotype Manifest In

Detailed Description

Statement

Reference

Male flies expressing Rdl^{dsRNA.4-5.Scer\UAS} under the control of Ilp2^Scer\UAS.cBa do not display an altered response to starvation compared to controls.

(Enell et al., 2010)

Scer\GAL4^c747-mediated expression of Rdl^{dsRNA.4-5.Scer\UAS} results in significantly enhanced learning after aversive olfactory conditioning (flies trained to associate odors with an electric shock).

(Liu et al., 2009)

Flies carrying four copies of Rdl^{dsRNA.4-5.Scer\UAS} driven by Scer\GAL4^c747 exhibit an enhanced performance in memory acquisition tests compared to controls, when trained with a 1 minute odour exposure paired with 1, 3 or 12 shocks.

(Liu et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Rdl^RNAi.4-5.UAS, Scer\GAL4^c747 is a non-enhancer of abnormal learning phenotype of Dop1R1^UAS.cLa, Scer\GAL4^c747

(Liu et al., 2009)

NOT Suppressor of

Statement

Reference

Scer\GAL4^c747/Rdl^RNAi.4-5.UAS is a non-suppressor of abnormal learning phenotype of Adcy1^rut-1

(Liu et al., 2009)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Scer\GAL4^c747-mediated expression of Rdl^{dsRNA.4-5.Scer\UAS} does not suppress the low learning performance of rut¹ flies after aversive olfactory conditioning or after appetitive olfactory conditioning.

Co-expression of Dop1R1^Scer\UAS.cLa and Rdl^{dsRNA.4-5.Scer\UAS} does not result in further enhancement of learning after aversive olfactory conditioning compared to expression of either single transgene.

(Liu et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

89904

w¹¹¹⁸; P{UAS-Rdl.RNAi.4-5}E

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Rdl^RNAi.4-5.UAS

Rdl^{dsRNA.4-5.Scer\UAS}

Rdl^{dsRNA.4-5.UAS}

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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