FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pli1
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General Information
Symbol
Dmel\Pli1
Species
D. melanogaster
Name
FlyBase ID
FBal0243659
Feature type
allele
Associated gene
Dmel\Pli
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Haghayeghi et al., 2010)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Pli1 mutants are pupal lethal, whereas Pli1 germ line clones have germ band retraction defects, but also twisted embryos and embryos with head involution defects. Pli1 germ line clones crossed to Df(3R)06624 show the same frequency of defects as crossed to Pli1. In contrast, Pli1 germ line clones crossed to paternally wild type flies show very few defects.

        Infection of Pli1 mutants with Micrococcus luteus strongly reduces their viability resulting in 50% lethality approximately 15 days earlier than in wild-type flies infected at the same time.

        (Haghayeghi et al., 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Pli1 is rescued by PliUAS.cHa

        (Haghayeghi et al., 2010)

        Pli1 is rescued by PliUAS.cHa/Scer\GAL4hs.PB

        (Haghayeghi et al., 2010)
        Comments

        Expressing PliScer\UAS.cHa with Scer\GAL4hs.PB using 1 hour heat shocks every day from first instar onwards rescues Pli1 homozygous mutants to viability. The survival of PliScer\UAS.cHa-carrying flies, in the absence of heat shock, can be increased to wild-type levels by removing infectious agents from their environment.

        (Haghayeghi et al., 2010)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        7T2
        (Haghayeghi et al., 2010)
        Pli1
        (Haghayeghi et al., 2010)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)