FB2026_03 , released September 17, 2026
Allele: Dmel\ushE5
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General Information
Symbol
Dmel\ushE5
Species
D. melanogaster
Name
FlyBase ID
FBal0243664
Feature type
allele
Associated gene
Dmel\ush
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Biryukova and Heitzler, 2008)
Mutagen
ethyl methanesulfonate
(Biryukova and Heitzler, 2008)
Progenitor genotype
Cytology
Description

Nonsense mutation resulting in a truncated (408 aa) protein, lacking the nuclear localisation site.

(Biryukova and Heitzler, 2008)

Amino acid replacement: Q409term.

(Biryukova and Heitzler, 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:537,250..537,250 [+]
Nucleotide change:

C537250T

Amino acid change:

Q409term | ush-PA; Q416term | ush-PB; Q409term | ush-PC; Q393term | ush-PD; Q416term | ush-PE

Reported amino acid change:

Q409term

Comment:

Site of mutation reported relative to ush-PA. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Biryukova and Heitzler, 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ushE5 homozygous embryos are U-shaped.

      ushE5/+ flies have the wildtype number of dorsocentral bristles.

      (Biryukova and Heitzler, 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ushE5/+; CtBPrev19/+ flies have the wildtype number of dorsocentral bristles.

      (Biryukova and Heitzler, 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ushE5
      (Biryukova and Heitzler, 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)