FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PGRP-SDΔ3
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General Information
Symbol
Dmel\PGRP-SDΔ3
Species
D. melanogaster
Name
FlyBase ID
FBal0243713
Feature type
allele
Associated gene
Dmel\PGRP-SD
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Bischoff et al., 2004)
Mutagen
P-element activity
(Bischoff et al., 2004)
Progenitor genotype
P{EPgy2}EY00423
(Bischoff et al., 2004)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 1499bp deletion that removes the PGRP-SD gene without affecting neighbouring open reading frames.

(Bischoff et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant flies are highly susceptible to S. aureus infection compared to wild-type adults.

      (Wang et al., 2008)

      Mutant flies show reduced survival compared to wild-type controls after infection with either S. pyogenes or S. aureus.

      Mutant flies show normal survival curves after infection with Cryptococcus neoformans.

      (Bischoff et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      PGRP-SDΔ3 GNBP1e03371 and PGRP-SDΔ3 PGRP-SAseml double mutant flies are extremely susceptible to S. aureus infection compared to wild-type adults.

      (Wang et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Expression of PGRP-SDScer\UAS.cBa under the control of Scer\GAL4hs.PB partially rescues the susceptibility of PGRP-SAseml ; PGRP-SDΔ3 double mutant flies to infection by S. pyogenes.

      (Bischoff et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      PGRP-SDΔ3
      (Davis et al., 2008, Wang et al., 2008, Bischoff et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)