FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CG86773602
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General Information
Symbol
Dmel\CG86773602
Species
D. melanogaster
Name
FlyBase ID
FBal0243735
Feature type
allele
Associated gene
Dmel\CG8677
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Jain et al., 2015)
Mutagen
Delta2-3 transposase
(Hanai et al., 2008)
Progenitor genotype
P{SUPor-P}CG8677KG02636
(Hanai et al., 2008)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 876bp deletion that eliminates the translational initiation codon, the first exon and part of the first intron of CG8677.

(Hanai et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:21,221,207..21,222,083 [+]
Comment:

876 bp deletion resulting from the imprecise excision of P{SUPor-P}CG8677KG02636. The deletion extends upstream from the insertion site, removing part of the first intron, the first exon (which contains the ATG), and upstream sequences.

(Hanai et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes are viable, fertile and phenotypically normal, with only approximately 10% of the homozygotes dying in the pupal stage (these animals have a melanotic tumor phenotype).

      The gross appearance of the polytene chromosomes appears normal in homozygous larvae and there is no change in the nucleosome repeat length of bulk chromatin isolated from mutant embryos compared to wild type.

      The position effect variegation at the w locus caused by In(1)wm4h is significantly suppressed by CG86773602/+ and more strongly suppressed by CG86773602/CG86773602.

      (Hanai et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      CG86773602 has suppressor of variegation | dominant phenotype, enhanceable by His2Av[+]/His2Av810

      (Hanai et al., 2008)

      CG86773602 has suppressor of variegation | dominant phenotype, enhanceable by reptunspecified/rept[+]

      (Hanai et al., 2008)
      Enhancer of
      Statement
      Reference

      CG8677[+]/CG86773602 is an enhancer of suppressor of variegation | dominant phenotype of His2Av810

      (Hanai et al., 2008)

      CG8677[+]/CG86773602 is an enhancer of suppressor of variegation | dominant phenotype of reptunspecified

      (Hanai et al., 2008)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      CG86773602/+ ; His2Av810/+ double heterozygotes show a synergistic effect on the position effect variegation at the w locus caused by In(1)wm4h, showing strong suppression of position effect variegation.

      CG86773602/+ ; reptunspecified/+ double heterozygotes show a synergistic effect on the position effect variegation at the w locus caused by In(1)wm4h, showing strong suppression of position effect variegation.

      (Hanai et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CG86773602
      Df(2L)dRsf-13602
      (Hanai et al., 2008)
      dRsf-13602
      (Hanai et al., 2008)
      rsf-13602
      (Jain et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)