FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\γCOPΔ114
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General Information
Symbol
Dmel\γCOPΔ114
Species
D. melanogaster
Name
FlyBase ID
FBal0244034
Feature type
allele
Associated gene
Dmel\γCOP
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Jayaram et al., 2008)
Progenitor genotype
P{SUPor-P}γCOPKG06383
(Jayaram et al., 2008)
Cytology
Description

Imprecise excision of the progenitor insertion has resulted in a deletion which removes the 5'UTR, first exon and the majority of the second exon.

(Jayaram et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At early stage 16, the dorsal trunk tubes of mutant embryos have a smaller diameter than those of controls, but dorsal trunk metamere length is normal. The smaller diameter of the dorsal trunk seen in mutant embryos can be detected by stage 14. Transepithelial barrier function in the trachea is normal in mutant embryos.

      The tracheal luminal matrix remains narrow and dense in early stage 16 mutant embryos.

      The salivary glands of mutant embryos are thinner than those of controls. Ultrastructurally, the salivary glands contain an atrophic, deformed and abnormally electron dense luminal matrix.

      Mutant embryos fail to complete dorsal closure.

      Endoplasmic reticulum structures are severely bloated in the dorsal trunk and salivary gland cells of mutant stage 16 embryos.

      (Jayaram et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Δ114
      (Jayaram et al., 2008)
      γCOPΔ114
      (Sekine et al., 2013)
      γCopΔ114
      Name Synonyms
      Secondary FlyBase IDs
        References (2)