FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fzrUAS.cKa
Open Close
General Information
Symbol
Dmel\fzrUAS.cKa
Species
D. melanogaster
Name
FlyBase ID
FBal0244062
Feature type
allele
Associated gene
Dmel\fzr
Associated Insertion(s)
Carried in Construct
P{UAS-fzr.K}
Key Links
Transgenic product class
wild_type
(Kaplow et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kaplow et al., 2008)
Mutagen
in vitro construct
(Kaplow et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-fzr.K}
Cytology
Description

UAS regulatory sequences drive expression of fzr coding sequences.

(Kaplow et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
fzr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of rapScer\UAS.cKa in larval brains (under the control of Scer\GAL4repo) results in a significant decrease in surface glia number. There is no change in the mitotic index or apoptosis in these mutants, indicating a decrease in differentiation.

      Expression of rapScer\UAS.cKa in larval brains (under the control of Scer\GAL4repo) results in a significant increase in the overall number of neurons in third instar larval brains and the number of surface neurons. The ectopic neuroblasts formed in these mutants are proliferative and maintain the potential to give rise to neurons.

      Expression of rapScer\UAS.cKa under the control of Scer\GAL4repo in MARCM clones within surface glia results in only 26% of the MARCM clone being repo positive. However, examination of the optic lobe or deeper regions of the larval brain such as the neuropile lineages results in 81% of the MARCM clones being repo positive.

      (Kaplow et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      fzrScer\UAS.cKa
      fzrUAS.cKa
      rapScer\UAS.cKa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)