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General Information
Symbol
Dmel\KCNQUAS.cOa
Species
D. melanogaster
Name
FlyBase ID
FBal0244111
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-KCNQ
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of KCNQ.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of KCNQ[UAS.cOa] under the control of Scer\GAL4elav.PU, Scer\GAL4c316, Scer\GAL4ey-OK107, Scer\GAL4[Mef2.247] or Scer\GAL4c305a does not lead to any significant change in 2 minute memory or 1 hour memory compared to controls.

Expression of KCNQScer\UAS.cOa in the heart under the control of "GHM5-GAL4" (Scer\GAL4Scer\UAS.cHa and Scer\GAL4tin.cBa), reverses the age-dependent increase in heart arrhythmias observed in wildtype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of KCNQScer\UAS.cOa under the control of Scer\GAL4how-24B in a KCNQ370 or KCNQ186 mutant background rescues the increased pacer-induced cardiac dysfunction rates and alterations in rhythmicity to levels comparable to those observed in control animals.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
KCNQScer\UAS.cOa
KCNQUAS.cOa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Ocorr
Secondary FlyBase IDs
    References (3)