FB2021_01, released Feb 18, 2021

Allele: Dmel\KCNQUAS.cOa

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General Information
Symbol
Dmel\KCNQUAS.cOa
Species
D. melanogaster
Name
FlyBase ID
FBal0244111
Feature type
allele
Associated gene
Dmel\KCNQ
Associated Insertion(s)
Carried in Construct
P{UAS-KCNQ.O}
Also Known As
UAS-KCNQ
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(Ocorr et al., 2007)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{UAS-KCNQ.O}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UAS regulatory sequences drive expression of KCNQ.

      (Ocorr et al., 2007)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      KCNQ
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of KCNQ[UAS.cOa] under the control of Scer\GAL4elav.PU, Scer\GAL4c316, Scer\GAL4ey-OK107, Scer\GAL4[Mef2.247] or Scer\GAL4c305a does not lead to any significant change in 2 minute memory or 1 hour memory compared to controls.

      (Cavaliere et al., 2013)

      Expression of KCNQScer\UAS.cOa in the heart under the control of "GHM5-GAL4" (Scer\GAL4Scer\UAS.cHa and Scer\GAL4tin.cBa), reverses the age-dependent increase in heart arrhythmias observed in wildtype.

      (Ocorr et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      KCNQUAS.cOa/Scer\GAL4Mef2.247 rescues KCNQ186

      (Cavaliere et al., 2013)

      KCNQUAS.cOa/Scer\GAL4ey-OK107 rescues KCNQ186

      (Cavaliere et al., 2013)

      KCNQUAS.cOa, Scer\GAL4how-24B, Scer\GAL4how-24B rescues KCNQ370

      (Ocorr et al., 2007)

      KCNQUAS.cOa, Scer\GAL4how-24B, Scer\GAL4how-24B rescues KCNQ186

      (Ocorr et al., 2007)
      Comments

      Expression of KCNQScer\UAS.cOa under the control of Scer\GAL4how-24B in a KCNQ370 or KCNQ186 mutant background rescues the increased pacer-induced cardiac dysfunction rates and alterations in rhythmicity to levels comparable to those observed in control animals.

      (Ocorr et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      KCNQScer\UAS.cOa
      KCNQUAS.cOa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Ocorr
      (Ocorr et al., 2007)
      Secondary FlyBase IDs
        References (3)