FlyBase Allele Report: Dmel\Nup107[E8]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\Nup107^E8

General Information

Symbol

Dmel\Nup107^E8

Species

D. melanogaster

Name

FlyBase ID

FBal0244137

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Katsani et al., 2008)

Progenitor genotype

P{EP}Nup107^EP2403

(Katsani et al., 2008)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion which removes 976bp from the Nup107 coding sequence, including the start codon.

(Katsani et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

2L:10,735,035..10,736,010 [-]

Comment:

976 bp deletion resulting from imprecise excision of P{EP}Nup107^EP2403

(Katsani et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal DNA repair | dominant

(Ryu et al., 2015)

female semi-fertile, with Nup107^D364N.mRFP1

(Weinberg-Shukron et al., 2015)

increased cell death | female, with Nup107^D364N.mRFP1

(Weinberg-Shukron et al., 2015)

lethal | recessive

(Weinberg-Shukron et al., 2015, Katsani et al., 2008)

majority die during embryonic stage, with Nup107^D364N.mRFP1

(Weinberg-Shukron et al., 2015)

Phenotype Manifest In

dorsal appendage, with Nup107^D364N.mRFP1

(Weinberg-Shukron et al., 2015)

egg chorion, with Nup107^D364N.mRFP1

(Weinberg-Shukron et al., 2015)

nurse cell, with Nup107^D364N.mRFP1

(Weinberg-Shukron et al., 2015)

ovariole, with Nup107^D364N.mRFP1

(Weinberg-Shukron et al., 2015)

Detailed Description

Statement

Reference

Nup107^E8/+ mutants exhibit significant genome instability in larval neuroblasts (in the absence of ionizing radiation), including aneuploidy, chromosome fusions and changes in the number of satellites.

(Ryu et al., 2015)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Nup107^E8 is rescued by Nup107^mRFP1

(Weinberg-Shukron et al., 2015)

Nup107^E8 is rescued by Nup107^mRFP1

(Katsani et al., 2008)

Partially rescued by

Nup107^E8 is partially rescued by Nup107^D364N.mRFP1

(Weinberg-Shukron et al., 2015)

Comments

Expression of Nup107^{T:Disc\RFP-mRFP} rescues the lethality of Nup107^E8/Nup107^E8 mutants, and results in no apparent morphological defects.

(Weinberg-Shukron et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (2)

35518

w^*; Nup107^E8/CyO; P{mRFP-Nup107.K}7.1, P{His2Av.GFP(S65T)}62A

35516

w^*; Nup107^E8, P{PTT-GB}LamC^G00158 ttv^G00158/CyO; P{mRFP-Nup107.K}7.1/TM2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Nup107^E8

(Shore et al., 2022, Hampoelz et al., 2016, Weinberg-Shukron et al., 2015)

nup107^E8

(Hampoelz et al., 2019, Ryu et al., 2015, Katsani et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections