FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\esclRNAi.UAS
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General Information
Symbol
Dmel\esclRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0244360
Feature type
allele
Associated gene
Dmel\escl
Associated Insertion(s)
Carried in Construct
P{UAS-escl.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Ohno et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ohno et al., 2008)
Mutagen
in vitro construct
(Ohno et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-escl.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of escl sequences.

(Ohno et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
escl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of two copies of escldsRNA.Scer\UAS under the control of Scer\GAL4Bx-MS1096 has little or no effect on the wing.

      (Ohno et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Scer\GAL4Bx-MS1096, escRNAi.UAS, esclRNAi.UAS has visible phenotype, suppressible by trx[+]/trxunspecified

      (Ohno et al., 2008)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Simultaneous expression of one copy each of escdsRNA.Scer\UAS and escldsRNA.Scer\UAS under the control of Scer\GAL4Bx-MS1096 results in a reduction in wing size and a curled wing phenotype.

      Simultaneous expression of two copies of escdsRNA.Scer\UAS and escldsRNA.Scer\UAS under the control of Scer\GAL4Bx-MS1096 results in a dramatic reduction of the wing blade.

      Simultaneous expression of escdsRNA.Scer\UAS and escldsRNA.Scer\UAS under the control of Scer\GAL4ey.PH results in variable phenotypes ranging from mild antenna to leg transformations, to dramatic reductions of the eye or of the entire head capsule.

      The wing defects caused by simultaneous expression of two copies of escdsRNA.Scer\UAS and escldsRNA.Scer\UAS under the control of Scer\GAL4Bx-MS1096 are completely suppressed by trxunspecified/+.

      (Ohno et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      esclRNAi.UAS
      escldsRNA.Scer\UAS
      escldsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)