FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\aPKCSG58
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General Information
Symbol
Dmel\aPKCSG58
Species
D. melanogaster
Name
FlyBase ID
FBal0244434
Feature type
allele
Associated gene
Dmel\aPKC
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ma et al., 2009)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      aPKCSG58/aPKC[+] is a suppressor of visible phenotype of DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF

      (Ma et al., 2009)

      aPKCSG58/aPKC[+] is a suppressor of abnormal neuroanatomy | adult stage phenotype of DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307

      (Ma et al., 2009)

      aPKCSG58/aPKC[+] is a suppressor of abnormal neurophysiology | adult stage phenotype of DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307

      (Ma et al., 2009)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      aPKCSG58/aPKC[+] is a suppressor of eye phenotype of DCTN1-p150Δ.UAS, Scer\GAL4GMR.PF

      (Ma et al., 2009)

      aPKCSG58/aPKC[+] is a suppressor of giant fiber neuron phenotype of DCTN1-p150Δ.UAS, Scer\GAL4shot-OK307

      (Ma et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      aPKCSG58 dominantly suppresses the eye phenotype caused by expression of GlΔ.Scer\UAS under the control of Scer\GAL4GMR.PF.

      aPKCSG58/+ mildly suppresses the swollen tip phenotype of giant fiber axons expressing GlΔ.Scer\UAS under the control of Scer\GAL4A307, but the lack of a terminal bend phenotype is not rescued.

      Heterozygosity for aPKCSG58 partially suppresses the giant fiber system electrophysiological defects in animals expressing GlΔ.Scer\UAS under the control of Scer\GAL4A307; all preparations respond to stimulation, there is a slight reduction in the long response latency and a corresponding increase in following to repetitive stimuli.

      (Ma et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      It has not been determined whether the lethality of the chromosome is caused by the mutation that modifies the eye phenotype caused by expression of GlΔ.Scer\UAS under the control of Scer\GAL4GMR.PF, so it is possible that the recessive lethality of the chromosome is due to a second-site mutation.

      (Ma et al., 2009)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      aPKCSG58
      Name Synonyms
      Secondary FlyBase IDs
        References (1)