UAS regulatory sequences drive expression of CycE coding sequences in which domain 1 (residues 254-262) is deleted, tagged at the N-terminus with Tag:MYC.
abnormal neuroanatomy, with Scer\GAL4sca-109-68
glial cell, with Scer\GAL4sca-109-68
neuroblast NB6-4, with Scer\GAL4sca-109-68
neuroblast NB6-4a, with Scer\GAL4sca-109-68
Expression of CycEΔdom1-1.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4sca-109-68 reduces the number of NB6-4a to NB6-4t transformations compared to wild-type. The number of NB6-4a neuroblasts that lead to more than 2 glia per lineage is also reduced in these mutants. However, CycEΔdom1-1.Scer\UAS.T:Hsap\MYC is still efficient in driving additional cell divisions.