FB2026_02 , released June 18, 2026
Allele: Dmel\Ube3aT447P.UAS.Tag:MYC
Open Close
General Information
Symbol
Dmel\Ube3aT447P.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0244603
Feature type
allele
Associated gene
Dmel\Ube3a
Associated Insertion(s)
Carried in Construct
P{UAS-Ube3a.T447P.3myc}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Wu et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Wu et al., 2008)
Mutagen
in vitro construct
(Wu et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-Ube3a.T447P.3myc}
Cytology
Description

UASt regulatory sequences drive expression of an Ube3a cDNA carrying a T447P substitution, fused in-frame at the N-terminus with 3 copies of Tag:MYC.

(Wu et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Ube3a
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:11,208,639..11,208,639 [-]
Nucleotide change:

A11208639C

Reported nucleotide change:

A?C

Amino acid change:

T447P | Ube3a-PA

Reported amino acid change:

T447P

Comment:

Analogous mutation in human UBE3A implicated in Angelman syndrome; mutation carried on in vitro construct.

(Wu et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Wu et al., 2008)
      UBE3A:p.Ser372Pro
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      UBE3A:p.Ser349Pro
      UBE3A:p.Ser369Pro
      Associated human disease model(s)
      External database links
      UniProtKB/Swiss-Prot variant: UBE3A_VAR_008143
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression Ube3aT447P.Scer\UAS.T:Hsap\MYC results in a variable phenotype depending upon the insertion line expressed. Ubiquitous expression, under the control of Scer\GAL4αTub84B.PL, does not alter viability for 4 of the 6 insertion lines, while the remaining 2 display lethality. Expression in the wing (under Scer\GAL4Bx-MS1096) or eye (under Scer\GAL4GMR.PF) results in no phenotype for 5 of the 6 insertion lines, but expression of the remaining insertion line results in rough eyes and curly wings.

      (Wu et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ube3aT447P.Scer\UAS.T:Hsap\MYC
      Ube3aT447P.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (3)