Dube3a, Angelman syndrome, As, das, Drosophila Angelman syndrome
Ubiquitination - protein degradation - model for Angelman syndrome - neuromuscular junction - regulation of the actin cytoskeleton, the formation of terminal dendritic branches, and dopamine/serotonin synthesis
Gene model reviewed during 5.45
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ube3a using the Feature Mapper tool.
Ube3a protein is broadly expressed, and mainly localized to the cytoplasm. Expression at post-embryonic stages is insufficiently robust to detect using immunocytochemistry. Ube3a protein is ubiquitously expressed in third star larvae, and is cytoplasmically localized. In the larval ventral nerve cord and brain , Ube3a protein expression is elevated in neuroblasts that are too young to express elav protein. Ube3a protein is expressed broadly in the adult brain, with particularly high levels in the mushroom bodies.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Ube3a in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Ube3a regulates monoamine synthesis by increasing GTP cyclohydrolase 1 activity via a non-ubiquitin ligase mechanism.
One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.