FlyBase Allele Report: Dmel\Ube3a[EP3214]

General Information

Symbol

Dmel\Ube3a^EP3214

Species

D. melanogaster

Name

FlyBase ID

FBal0131444

Feature type

allele

Associated gene

Dmel\Ube3a

Associated Insertion(s)

P{EP}Ube3a^EP3214

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EP}Ube3a^EP3214

Cytology

Description

P{EP}As^EP3214 is located in the first exon of As, 293nt upstream of the ATG start codon.

(Lu et al., 2009)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:11,210,495..11,210,495 [+]

(Lu et al., 2009, Wu et al., 2008, Wu et al., 2008, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of autism spectrum disorder

CEA

(Dong et al., 2016)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning | adult stage

(Dong et al., 2016)

abnormal memory | adult stage

(Dong et al., 2016)

lethal | recessive

(Lu et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Ube3a^EP3214/Ube3a^EP3214 mutants do not exhibit defective learning in an aversive conditioning assay, but do exhibit defects in a reversal-learning paradigm, with a third-odor preference assay showing an inability to forget the first aversive odor association after training with a second aversive odor, although the ability to learn new behavior patterns is normal, as compared to wild type.

(Dong et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Ube3a^EP3214/Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

NOT Suppressor of

Statement

Reference

Ube3a^EP3214/Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Ube3a^EP3214/Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

NOT Suppressor of

Statement

Reference

Ube3a^EP3214/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

17099

w¹¹¹⁸; P{EP}Ube3a^EP3214

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

As^EP3214

CG6190^EP3214

Ube3a^EP3214

(Dong et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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