FlyBase Allele Report: Dmel\Ube3a[Δ3-8]

General Information

Symbol

Dmel\Ube3a^Δ3-8

Species

D. melanogaster

Name

FlyBase ID

FBal0241527

Feature type

allele

Associated gene

Dmel\Ube3a

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Lu et al., 2009)

Mutagen

P-element activity

(Lu et al., 2009)

Progenitor genotype

Ube3a^EP3214

(Lu et al., 2009)

Caused by aberration

Df(3L)Δ3-8

Cytology

Description

Imprecise excision of P{EP}As^EP3214 removes part of the As and CG7600 coding regions.

(Lu et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Lu et al., 2009)

abnormal neuroanatomy (with Ube3a^Δ15-8)

(Lu et al., 2009)

viable

(Lu et al., 2009)

Phenotype Manifest In

larval dorsal multidendritic neuron ddaC

(Lu et al., 2009)

larval dorsal multidendritic neuron ddaC (with Ube3a^Δ15-8)

(Lu et al., 2009)

larval dorsal multidendritic neuron ddaE

(Lu et al., 2009)

larval dorsal multidendritic neuron ddaF

(Lu et al., 2009)

Detailed Description

Statement

Reference

Transheterozygous As^Δ15-8/As^Δ3-8 third instar mutant larval ddaC neurons exhibit a significantly reduced number of dendritic terminal branches, although the overall branching patterns of ddaC neurons in the A3 segment, especially the primary and secondary branches, remain the same as in wild-type larvae.

Terminal dendritic branches of ddaC neurons in As^Δ15-8/As^Δ3-8 transheterozygous mutants are much shorter than in wild-type, with patches of the target field devoid of dendrites.

As^Δ3-8 mutant ddaC neurons (in an otherwise wild-type larva) exhibit defective dendritic growth (with fewer terminal dendritic branches) and branching.

The number of dendritic branches is decreased in ddaE and ddaF neurons that are homozygous for As^Δ3-8.

(Lu et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Associated with: CG7600^Δ39-12.

(Lu et al., 2009)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

As^Δ3-8

Ube3a^Δ3-8

dUBE3A^Δ3-8

(Lu et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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