FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ube3aTag:MYC
Open Close
General Information
Symbol
Dmel\Ube3aTag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0244609
Feature type
allele
Associated gene
Dmel\Ube3a
Associated Insertion(s)
Carried in Construct
P{Ube3a.6myc}
Key Links
Transgenic product class
wild_type
(Wu et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wu et al., 2008)
Mutagen
in vitro construct
(Wu et al., 2008)
Progenitor genotype
Carried in construct
P{Ube3a.6myc}
Cytology
Description

13kb DNA fragment spanning Ube3a, tagged with 6 copies of Tag:MYC at the N-terminus of Ube3a.

(Wu et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
Ube3a
Encoded product / tool
Ube3a
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter or direct label
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      third instar larval stage
      thoracic neuroblast
      (Wu et al., 2008)
      abdominal neuroblast
      (Wu et al., 2008)
      neuroblast of larval brain
      (Wu et al., 2008)
      wandering third instar larval stage
      eye disc
      (Wu et al., 2008)
      adult stage
      gustatory receptor neuron of the labellum | subset
      (Zhang et al., 2013)
      adult brain
      (Wu et al., 2008)
      adult mushroom body
      (Wu et al., 2008)
      Additional Information
      Statement
      Reference

      Expression at post-embryonic stages is insufficiently robust to detect using immunocytochemistry. Ube3a protein is ubiquitously expressed in third star larvae, and is cytoplasmically localized. In the larval ventral nerve cord and brain , Ube3a protein expression is elevated in neuroblasts that are too young to express elav protein. Ube3a protein is expressed broadly in the adult brain, with particularly high levels in the mushroom bodies.

      (Wu et al., 2008)
       
      Marker for
      Reflects expression of
      Ube3a
      (Zhang et al., 2013, Wu et al., 2008)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  intellectual disability
      CEA
      (Chakraborty et al., 2015)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults carrying a maternally inherited copy of Ube3aT:Hsap\MYC show learning defects (significantly reduced performance in a aversive phototaxis suppression assay compared to controls).

      Adults carrying two copies of Ube3aT:Hsap\MYC (one paternally inherited, one maternally inherited) show learning defects (significantly reduced performance in a aversive phototaxis suppression assay compared to controls).

      (Chakraborty et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Ube3aTag:MYC rescues Ube3a15B

      (Zhang et al., 2013)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ube3aT:Hsap\MYC
      Ube3aTag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (4)