FlyBase Allele Report: Dmel\Ube3a[unspecified]

General Information

Symbol

Dmel\Ube3a^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0316239

Feature type

allele

Associated gene

Dmel\Ube3a

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of intellectual disability

CEA

(Chakraborty et al., 2015)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of intellectual disability

is ameliorated by Hsap\UBE3A^UAS.iso1.cCa

(Chakraborty et al., 2015)

is ameliorated by drl^UAS.cCa

(Chakraborty et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning | adult stage | dominant | maternal effect

(Chakraborty et al., 2015)

abnormal learning | dominant | larval stage | maternal effect

(Chakraborty et al., 2015)

abnormal neuroanatomy | adult stage | recessive

(Chakraborty et al., 2015)

Phenotype Manifest In

adult mushroom body alpha-lobe

(Chakraborty et al., 2015)

adult mushroom body beta-lobe

(Chakraborty et al., 2015)

Detailed Description

Statement

Reference

Heterozygous adults which have a maternally inherited null mutation of Ube3a show learning defects (significantly reduced performance in a aversive phototaxis suppression assay compared to controls).

Heterozygous larvae which have a maternally inherited null mutation of Ube3a show learning defects (reduced performance in a taste-aversion paradigm).

Homozygous adults have severe defects in the mushroom body, including fused β-lobes and missing or folded α-lobes.

Heterozygous adults which have a maternally inherited null mutation of Ube3a do not show mushroom body defects.

(Chakraborty et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Ube3a^unspecified has abnormal learning | dominant | maternal effect phenotype, suppressible by drl^UAS.cCa/Scer\GAL4^elav.PU

(Chakraborty et al., 2015)

Ube3a^unspecified has abnormal learning | dominant | maternal effect | adult stage phenotype, suppressible by Hsap\UBE3A^UAS.iso1.cCa/Scer\GAL4^elav.PU

(Chakraborty et al., 2015)

Ube3a^unspecified has abnormal learning | dominant | maternal effect | larval stage phenotype, suppressible by Hsap\UBE3A^UAS.iso1.cCa/Scer\GAL4^elav.PU

(Chakraborty et al., 2015)

NOT suppressed by

Statement

Reference

Ube3a^unspecified has abnormal learning | dominant | maternal effect | adult stage phenotype, non-suppressible by Hsap\UBE3A^UAS.iso1.cCa/Scer\GAL4^Tab2-201Y

(Chakraborty et al., 2015)

Ube3a^unspecified has abnormal learning | dominant | maternal effect | adult stage phenotype, non-suppressible by Hsap\UBE3A^UAS.iso1.cCa/Scer\GAL4^ey-OK107

(Chakraborty et al., 2015)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Expression of drl^Scer\UAS.cCa under the control of Scer\GAL4^elav.PU rescues the learning defects seen in flies which have a maternally inherited null mutation of Ube3a.

(Chakraborty et al., 2015)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\UBE3A^{Scer\UAS.iso1.cCa} under the control of Scer\GAL4^elav.PU rescues the learning defects seen in larvae and adults which have a maternally inherited null mutation of Ube3a.

Expression of Hsap\UBE3A^{Scer\UAS.iso1.cCa} under the control of either Scer\GAL4^Tab2-201Y or Scer\GAL4^ey-OK107 does not rescue the learning defects seen in adults which have a maternally inherited null mutation of Ube3a.

(Chakraborty et al., 2015)

Complementation and Rescue Data

Rescued by

Ube3a^unspecified is rescued by Scer\GAL4^elav.PU/Ube3a^UAS.cWa

(Chakraborty et al., 2015)

Not rescued by

Ube3a^unspecified is not rescued by Ube3a^C941A.UAS/Scer\GAL4^elav.PU

(Chakraborty et al., 2015)

Comments

Expression of Ube3a^Scer\UAS.cWa, but not Ube3a^{C941A.Scer\UAS}, under the control of Scer\GAL4^elav.PU rescues the learning defects (reduced performance in a aversive phototaxis suppression assay) of adults which have a maternally inherited null mutation of Ube3a.

(Chakraborty et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ube3a^unspecified

dube3a^-

(Chakraborty et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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