FlyBase Allele Report: Dmel\Ube3a[Δ15-8]

General Information

Symbol

Dmel\Ube3a^Δ15-8

Species

D. melanogaster

Name

FlyBase ID

FBal0241530

Feature type

allele

Associated gene

Dmel\Ube3a

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Lu et al., 2009)

Mutagen

P-element activity

(Lu et al., 2009)

Progenitor genotype

Ube3a^EP3214

(Lu et al., 2009)

Cytology

Description

Imprecise excision of P{EP}As^EP3214 leaves a 1.1kb DNA fragment from P{EP}As^EP3214 in As.

(Lu et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Lu et al., 2009)

abnormal neuroanatomy, with Scer\GAL4⁴⁷⁷, Ube3a^GD450

(Lu et al., 2009)

abnormal neuroanatomy (with Ube3a^Δ3-8)

(Lu et al., 2009)

viable

(Lu et al., 2009)

Phenotype Manifest In

larval dorsal multidendritic neuron ddaC

(Lu et al., 2009)

larval dorsal multidendritic neuron ddaC, with Scer\GAL4⁴⁷⁷, Ube3a^GD450

(Lu et al., 2009)

larval dorsal multidendritic neuron ddaC (with Ube3a^Δ3-8)

(Lu et al., 2009)

larval dorsal multidendritic neuron ddaE

(Lu et al., 2009)

larval dorsal multidendritic neuron ddaF

(Lu et al., 2009)

Detailed Description

Statement

Reference

Homozygous As^Δ15-8 and transheterozygous As^Δ15-8/As^Δ3-8 third instar mutant larval ddaC neurons exhibit a significantly reduced number of dendritic terminal branches, although the overall branching patterns of ddaC neurons in the A3 segment, especially the primary and secondary branches, remain the same as in wild-type larvae.

Terminal dendritic branches of ddaC neurons in homozygous As^Δ15-8 and As^Δ15-8/As^Δ3-8 transheterozygous mutants are much shorter than in wild-type, with patches of the target field devoid of dendrites.

As^Δ15-8 mutant ddaC neurons (in an otherwise wild-type larva) exhibit defective dendritic growth (with fewer terminal dendritic branches) and branching.

The number of dendritic branches is decreased in ddaE and ddaF neurons that are homozygous for As^Δ15-8.

(Lu et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ube3a^Δ15-8 has abnormal neuroanatomy phenotype, enhanceable by eff^mer4

(Lu et al., 2009)

Ube3a^Δ15-8 has abnormal neuroanatomy phenotype, enhanceable by eff^s1782

(Lu et al., 2009)

Enhancer of

Statement

Reference

Ube3a^Δ15-8 is an enhancer of abnormal neuroanatomy phenotype of eff^mer4

(Lu et al., 2009)

Ube3a^Δ15-8 is an enhancer of abnormal neuroanatomy phenotype of eff^s1782

(Lu et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ube3a^Δ15-8 has larval dorsal multidendritic neuron ddaC phenotype, enhanceable by eff^mer4

(Lu et al., 2009)

Ube3a^Δ15-8 has larval dorsal multidendritic neuron ddaC phenotype, enhanceable by eff^s1782

(Lu et al., 2009)

Enhancer of

Statement

Reference

Ube3a^Δ15-8 is an enhancer of larval dorsal multidendritic neuron ddaC phenotype of eff^mer4

(Lu et al., 2009)

Ube3a^Δ15-8 is an enhancer of larval dorsal multidendritic neuron ddaC phenotype of eff^s1782

(Lu et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Third-instar larva transheterozygous for As^Δ15-8 and eff^mer4 exhibit a severe reduction in the number of terminal dendritic branches of ddaC neurons compared to the single mutant heterozygotes.

Third-instar larva transheterozygous for As^Δ15-8 and eff^s1782 exhibit a severe reduction in the number of terminal dendritic branches of ddaC neurons compared to the single mutant heterozygotes.

(Lu et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

As^Δ15-8

Ube3a^Δ15-8

dUBE3A^Δ15-8

(Lu et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close