FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ykiS168A.UAS.cRa.Tag:MYC
Open Close
General Information
Symbol
Dmel\ykiS168A.UAS.cRa.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0244976
Feature type
allele
Associated gene
Dmel\yki
Associated Insertion(s)
Carried in Construct
M{UAS-Myc-yki.S168A}
Key Links
Transgenic product class
missense_variant
(Ren et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Ren et al., 2010)
Mutagen
in vitro construct
(Ren et al., 2010)
Progenitor genotype
Carried in construct
M{UAS-Myc-yki.S168A}
Cytology
Description

UAS regulatory sequences drive expression of mutant form of yki (containing the amino acid replacement S168A) which is tagged with Tag:MYC.

(Ren et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
yki
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ykiS168A.UAS.cRa.Tag:MYC under the control of Scer\GAL4GMR.PF leads to an increase in eye size when compared to controls.

      (Cho et al., 2018)

      Expression of ykiS168A.Scer\UAS.cRa.T:Hsap\MYC under the control of Scer\GAL4GMR.PU results in overgrowth and folding in the adult eye.

      (Hu et al., 2016)

      Expression of ykiS168A.Scer\UAS.cRa.T:Hsap\MYC under the control of Scer\GAL4GMR.PF results in a strong eye overgrowth phenotype.

      (Ren et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Suppressed by
      Statement
      Reference

      Scer\GAL4GMR.PF, ykiS168A.UAS.cRa.Tag:MYC has eye phenotype, suppressible by Prp4kUAS.GFP, Scer\GAL4GMR.PF

      (Cho et al., 2018)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The overgrowth and folding of the adult eye induced by expression of ykiS168A.Scer\UAS.cRa.T:Hsap\MYC under the control of Scer\GAL4GMR.PU is significantly exacerbated by co-expression of AckScer\UAS.T:SV5\V5 but not AckKD.Scer\UAS.T:SV5\V5.

      (Hu et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Generated by integration of an attB containing construct into a M{3xP3-RFP.attP} docking site at 75B1.

      (Ren et al., 2010)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ykiS168A.Scer\UAS.cRa.T:Hsap\MYC
      ykiS168A.UAS.cRa.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (4)