FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\BthDRNAi.UAS
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General Information
Symbol
Dmel\BthDRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0245017
Feature type
allele
Associated gene
Dmel\BthD
Associated Insertion(s)
Carried in Construct
P{UAS-BthD.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Kwon et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Kwon et al., 2003)
Mutagen
in vitro construct
(Kwon et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-BthD.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of BthD sequences, consisting of a genomic fragment and an inverted cDNA fragment.

(Kwon et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
BthD
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of BthDdsRNA.Scer\UAS under the control of either Scer\GAL4fkh.PH or Scer\GAL4da.G32 does not significantly affect embryonic or larval survival, but the number of adult flies that are recovered is significantly reduced, with most lethality occurring shortly after pupariation.

      Expression of BthDdsRNA.Scer\UAS under the control of either Scer\GAL4fkh.PH or Scer\GAL4da.G32 results in a reduction in cell size in third larval instar salivary glands, with the glands being significantly smaller and the nuclei more closely packed than in controls. The total number of cells is not decreased in the mutant salivary glands.

      Expression of BthDdsRNA.Scer\UAS under the control of Scer\GAL4da.G32 has no effect on imaginal disc or gut morphology in third instar larvae.

      (Kwon et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      BthDRNAi.UAS
      BthDdsRNA.Scer\UAS
      BthDdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)