FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nrx-1313
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General Information
Symbol
Dmel\Nrx-1313
Species
D. melanogaster
Name
FlyBase ID
FBal0245099
Feature type
allele
Associated gene
Dmel\Nrx-1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
transposable element activity
(Chen et al., 2010)
Progenitor genotype
Mi{ET1}Nrx-1MB00002
(Chen et al., 2010)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 10bp deletion in intron 7 approximately 3kb from the site of the original insertion.

(Chen et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:22,476,745..22,476,754 [+]
Comment:

10 bp deletion in intron 7 of Nrx-1 resulting from the excision of Mi{ET1}Nrx-1MB00002. The insertion is completely excised in the Nrx-1313 mutant.

(Chen et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Neuromuscular junction (NMJ) size and the number of active zones/NMJ are significantly reduced in Nrx-1313/Df(3R)Exel6191 embryos compared to wild type, while active zone density within the NMJ and active zone size are unaffected.

      The amplitude of the evoked excitatory junction current (EJC) is reduced in Nrx-1313/Df(3R)Exel6191 embryonic NMJs compared to wild type, while the frequency of spontaneous EJCs is unaffected. There is no change in the amplitude of glutamate-gated currents at the NMJ in these embryos.

      (Chen et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Nrx-1241

      (Chen et al., 2010)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Nrx-1313
      nrx313
      (Chen et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)