FlyBase Allele Report: Dmel\Nrx-1[241]

General Information

Symbol

Dmel\Nrx-1²⁴¹

Species

D. melanogaster

Name

FlyBase ID

FBal0241962

Feature type

allele

Associated gene

Dmel\Nrx-1

Associated Insertion(s)

Carried in Construct

Also Known As

dnrx²⁴¹, nrx²⁴¹

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Li et al., 2007)

Mutagen

P-element activity

(Li et al., 2007)

Progenitor genotype

Nrx-1^d08766

(Li et al., 2007)

Cytology

Description

Imprecise excision of P{XP}Nrx-1^d08766 results in deletion of the entire Nrx-1 locus, plus the upstream region of an adjacent transcription unit.

(Li et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of autism spectrum disorder

CEA

(Levy et al., 2022)

CEA with Nrx-1²⁷³

(Levy et al., 2022)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage (with Df(3R)Exel6191)

(Banovic et al., 2010)

abnormal neuroanatomy | pharate adult stage (with Df(3R)Exel6191)

(Constance et al., 2018)

abnormal neuroanatomy | third instar larval stage (with Df(3R)5C1)

(Ramesh et al., 2021, Owald et al., 2012)

decreased size | third instar larval stage (with Df(3R)5C1)

(Ramesh et al., 2021)

uncoordinated | larval stage (with Nrx-1²⁷³)

(Li et al., 2007)

viable (with Df(3R)Exel6191)

(Constance et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

At late pharate adult stage in Nrx-1²⁴¹/Df(3R)Exel6191 flies, persistent motor neurons which innervate the abdominal lateral tergosternal muscles display significantly reduced total axonal arbor length and area of arbor coverage, but no differences between total branch numbers and arbor complexity compared to wild-type controls. Additionally, there is no difference in synaptic density in motor neuron axons in the adult.

(Constance et al., 2018)

Nrx-1²⁴¹/+ mutant larvae do not display any obvious defects in neuromuscular junction and active zone morphology, as compared to controls.

(Muhammad et al., 2015)

T-bars at active zones of the neuromuscular junction in Nrx-1²⁴¹/Df(3R)5C1 third instar larvae often show an aberrant, star-shaped morphology.

(Owald et al., 2012)

The neuromuscular junctions of Nrx-1²⁴¹/Df(3R)Exel6191 larvae are smaller than normal.

(Banovic et al., 2010)

Nrx-1²⁷³/Nrx-1²⁴¹ heterozygous larva exhibit severely impaired behavior in larval stages, being uncoordinated and sluggish.

(Li et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Nrx-1²⁴¹/Df(3R)5C1 is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Nlg1^{Δcyto.UAS.EGFP}, Scer\GAL4^Mef2.PR

(Owald et al., 2012)

Phenotype Manifest In

Suppressed by

Statement

Reference

Nrx-1²⁴¹/Df(3R)5C1 has presynaptic active zone | decreased number phenotype, suppressible by Df(3L)Spn-Δ3.1/+

(Ramesh et al., 2021)

Nrx-1²⁴¹/Df(3R)5C1 has presynaptic active zone phenotype, suppressible by Df(3L)Spn-Δ3.1/+

(Ramesh et al., 2021)

Nrx-1²⁴¹/Df(3R)5C1 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, suppressible by Df(3L)Spn-Δ3.1/+

(Ramesh et al., 2021)

Nrx-1²⁴¹/Df(3R)5C1 has muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage phenotype, suppressible by Df(3L)Spn-Δ3.1/+

(Ramesh et al., 2021)

NOT suppressed by

Statement

Reference

Nrx-1²⁴¹/Df(3R)5C1 has presynaptic active zone | decreased number phenotype, non-suppressible by Nlg2[+]/Nlg2^CL5

(Ramesh et al., 2021)

Nrx-1²⁴¹/Df(3R)5C1 has presynaptic active zone phenotype, non-suppressible by Nlg2[+]/Nlg2^CL5

(Ramesh et al., 2021)

Nrx-1²⁴¹/Df(3R)5C1 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, non-suppressible by Nlg2[+]/Nlg2^CL5

(Ramesh et al., 2021)

Nrx-1²⁴¹/Df(3R)5C1 has muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage phenotype, non-suppressible by Nlg2[+]/Nlg2^CL5

(Ramesh et al., 2021)

Suppressor of

Statement

Reference

Nrx-1[+]/Nrx-1²⁴¹ is a suppressor of presynaptic active zone | increased number phenotype of Nlg2^CL5

(Ramesh et al., 2021)

Nrx-1[+]/Nrx-1²⁴¹ is a suppressor of presynaptic active zone phenotype of Nlg2^CL5

(Ramesh et al., 2021)

Nrx-1[+]/Nrx-1²⁴¹ is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Nlg2^CL5

(Ramesh et al., 2021)

Nrx-1[+]/Nrx-1²⁴¹ is a suppressor of muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage phenotype of Nlg2^CL5

(Ramesh et al., 2021)

Nrx-1²⁴¹/Df(3R)5C1 is a suppressor of NMJ bouton | third instar larval stage phenotype of Nlg1^{Δcyto.UAS.EGFP}, Scer\GAL4^Mef2.PR

(Owald et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Nrx-1²⁴¹/+ suppresses the neuromuscular junction phenotypes seen in Df(3L)Spn-Δ3.1/Df(3L)BSC116 mutants.

(Muhammad et al., 2015)

The reduction in bouton number per muscle area seen in third instar larvae expressing Nlg1^{Δcyto.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^Mef2.PR is suppressed in a Nrx-1²⁴¹/Df(3R)5C1 background.

(Owald et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Nrx-1²⁴¹

(Levy et al., 2022, Muhammad et al., 2015, Owald et al., 2012)

Nrx²⁴¹

(Constance et al., 2018)

dnrx²⁴¹

(Zhang et al., 2018, Banovic et al., 2010, Li et al., 2007)

nrx-1²⁴¹

(Ramesh et al., 2021)

nrx²⁴¹

(Chen et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (10)

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