FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ssp598
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General Information
Symbol
Dmel\ssp598
Species
D. melanogaster
Name
FlyBase ID
FBal0245179
Feature type
allele
Associated gene
Dmel\ssp
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Taniue et al., 2010)
Progenitor genotype
P{lacW}sspP
(Taniue et al., 2010)
Cytology
Description

Imprecise excision of P{lacW}sspP resulting in a deletion of about 600 bp that extends from a position 60 bp downstream of the presumptive ssp transcription start site.

(Taniue et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:12,118,303..12,118,903 [+]
Comment:

Approximate boundaries of a deletion resulting from the imprecise excision of P{lacW}sspP, reported as a ~600bp deletion starting 60bp downstream of the ssp transcription start site and extending into the gene.

(Taniue et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The imaginal discs, salivery glands and central nervous system of homozygotes are smaller than those of their wild type counterparts. The imaginal discs of hemizygous (ssp598/Df(3L)BK9) larvae are also smaller compared to wild type.

      Homozygotes reach the third instar stage but fail to pupate and die between 10 and 20 days after egg laying.

      Melanotic pseudotumors form in homozygous or hemizygous (ssp598/Df(3L)BK9) larvae. One or more pseudotumors first appear at 6 days after egg laying and their number and size increase during larval development.

      Clones generated in the presumptive wing blade underogo only a few divisions - the mutants cells proliferate slowly and either die or are actively eliminated from the epithelium.

      The nuclear size of mutant cells in the distal region of the salivary gland is smaller than that of wild type distal cells.

      Very few nuclei incorporate BrdU in ssp598 salivary glands.

      (Taniue et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      ssp598, versj2D3 has viable phenotype

      (Taniue et al., 2010)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ssp598 fully complements the phenotype of l(3)j2D3j2D3.

      (Taniue et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      ssp598 is rescued by Scer\GAL4arm.PS/sspUAS.GFP

      (Taniue et al., 2010)
      Comments

      Expression of sspScer\UAS.T:Avic\GFP using Scer\GAL4arm.PS rescues the lethality and other phenotypes associated with ssp598 homozygotes.

      (Taniue et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ssp598
      (Taniue et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)