FB2026_02 , released June 18, 2026
Allele: Dmel\ana1mecB
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General Information
Symbol
Dmel\ana1mecB
Species
D. melanogaster
Name
FlyBase ID
FBal0245278
Feature type
allele
Associated gene
Dmel\ana1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide numbering relative to ATG; amino acid numbering based on PA isoform.

    (Blachon et al., 2009)

    Nucleotide substitution: C3368T.

    (Blachon et al., 2009)

    Amino acid replacement: Q1120term.

    (Blachon et al., 2009)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:24,534,353..24,534,353 [+]
    Nucleotide change:

    C24534353T

    Reported nucleotide change:

    C3368T

    Amino acid change:

    Q1120term | ana1-PA; Q1120term | ana1-PC

    Reported amino acid change:

    Q1120term

    (Blachon et al., 2009)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Wing discs of ana1mecB/Df(3R)Exel7357, ana1Ubi.GFP individuals show over-elongation of centrioles.

        ana1mecB/Df(3R)Exel7357, ana1S34T.Ubi.GFP males have fewer progeny and their spermatids show shorter centrioles than controls. ana1mecB/Df(3R)Exel7357, ana1S34T.Ubi.mCherry males also have fewer progeny.

        Embryos from ana1mecB/Df(3R)Exel7357, ana1S34T.Ubi.GFP mothers show mitotic defects and centrosomal defects (duplicated/clustered centrosomes, centrosomes shared by 2 spindles, spindles poles lacking centrosomes, detached centrosomes). Unlike controls, centrosomes fail to accumulate substantial PCM scaffold.

        (Alvarez-Rodrigo et al., 2021)

        Mechanosensory neurons lack the tubular body but retain a dendritic sheath. At the base of the cilium, the basal body is absent.

        Axonemes are missing in sperm tails and the sperm are immotile.

        At 18[o]C, flies are uncoordinated, their legs are crossed and their wings extend upwards.

        (Blachon et al., 2009)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        References (7)