FlyBase Allele Report: Dmel\ana1[null]

General Information

Symbol

Dmel\ana1^null

Species

D. melanogaster

Name

FlyBase ID

FBal0407321

Feature type

allele

Associated gene

Dmel\ana1

Associated Insertion(s)

TI{TI}ana1^null

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Nagy et al., 2025)

Mutagen

CRISPR/Cas9

(Nagy et al., 2025)

gene targeting by homologous recombination

(Nagy et al., 2025)

Progenitor genotype

Associated Insertion(s)

TI{TI}ana1^null

Cytology

Description

Exons 1-3 and part of exon 4 of endogenous ana1 are replaced with a Disc\RFP^{DsRed.3xP3.cUa} marker and transcriptional terminator, flanked by loxP sites.

(Nagy et al., 2025)

Allele components

Component

Use(s)

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased rate of adult locomotory behavior (with Df(3R)Exel7357)

(Nagy et al., 2025)

decreased size | spermatogenesis, with ana1^1-935.mRFP1, ana1^715-1729

(Nagy et al., 2025)

decreased size | spermatogenesis, with ana1^Δ1341-1471

(Nagy et al., 2025)

decreased size | spermatogenesis, with ana1^Δ1472-1602

(Nagy et al., 2025)

male sterile, with ana1^1-935.mRFP1, ana1^715-1729

(Nagy et al., 2025)

male sterile, with ana1^Δ1341-1471

(Nagy et al., 2025)

male sterile, with ana1^Δ1472-1602

(Nagy et al., 2025)

partially lethal (with Df(3R)Exel7357)

(Nagy et al., 2025)

uncoordinated (with Df(3R)Exel7357)

(Nagy et al., 2025)

uncoordinated | adult stage

(Nagy et al., 2025)

uncoordinated | adult stage (with ana1^mecB)

(Nagy et al., 2025)

uncoordinated | adult stage (with ana1^Δ1-762)

(Nagy et al., 2025)

Phenotype Manifest In

centriole, with ana1^{1-935.Ubi.mRFP1}

(Nagy et al., 2025)

centriole | decreased number | spermatogenesis, with ana1^1-935.mRFP1

(Nagy et al., 2025)

centriole | spermatogenesis, with ana1^1-935.mRFP1, ana1^715-1729

(Nagy et al., 2025)

centriole | spermatogenesis, with ana1^Δ1341-1471

(Nagy et al., 2025)

centriole | spermatogenesis, with ana1^Δ1472-1602

(Nagy et al., 2025)

ciliary basal body, with ana1^{1-935.Ubi.mRFP1}

(Nagy et al., 2025)

ciliary basal body (with Df(3R)Exel7357)

(Nagy et al., 2025)

cilium (with Df(3R)Exel7357)

(Nagy et al., 2025)

femoral chordotonal organ, with ana1^{1-935.Ubi.mRFP1}

(Nagy et al., 2025)

femoral chordotonal organ (with Df(3R)Exel7357)

(Nagy et al., 2025)

primary spermatocyte | spermatogenesis, with ana1^1-935.mRFP1, ana1^715-1729

(Nagy et al., 2025)

spermatid | spermatogenesis, with ana1^1-935.mRFP1, ana1^715-1729

(Nagy et al., 2025)

spermatocyte, with ana1^1-935.mRFP1

(Nagy et al., 2025)

spermatocyte, with ana1^Δ1341-1471

(Nagy et al., 2025)

spermatocyte, with ana1^Δ1472-1602

(Nagy et al., 2025)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ana1^null is rescued by ana1^1-706.Ubi/ana1^{545-1729.Ubi.GFP}

(Nagy et al., 2025)

ana1^null is rescued by ana1^715-1729/ana1^{1-935.Ubi.mRFP1}

(Nagy et al., 2025)

ana1^null is rescued by ana1^{715-1729.Ubi.GFP}/ana1^{1-935.Ubi.mRFP1}

(Nagy et al., 2025)

ana1^null is rescued by ana1^mRFP1

(Nagy et al., 2025)

Partially rescued by

ana1^null is partially rescued by ana1^715-1729/ana1^1-1120.mRFP1

(Nagy et al., 2025)

ana1^null is partially rescued by ana1^820-1729/ana1^1-1120.mRFP1

(Nagy et al., 2025)

ana1^null is partially rescued by ana1^820-1729/ana1^{1-935.Ubi.mRFP1}

(Nagy et al., 2025)

ana1^null is partially rescued by ana1^1-935.mRFP1/ana1^715-1729

(Nagy et al., 2025)

ana1^null is partially rescued by ana1^820-1729/ana1^1-935.mRFP1

(Nagy et al., 2025)

Not rescued by

ana1^null is not rescued by ana1^1-1120.mRFP1

(Nagy et al., 2025)

ana1^null is not rescued by ana1^715-1729/ana1^1-1120.mRFP1

(Nagy et al., 2025)

ana1^null is not rescued by ana1^1-1120.mRFP1/ana1^975-1729

(Nagy et al., 2025)

ana1^null is not rescued by ana1^1-1200.mRFP1

(Nagy et al., 2025)

ana1^null is not rescued by ana1^1-1430.mRFP1

(Nagy et al., 2025)

ana1^null is not rescued by ana1^1-1430.mRFP1/ana1^715-1729

(Nagy et al., 2025)

ana1^null is not rescued by ana1^1-706.Ubi

(Nagy et al., 2025)

ana1^null is not rescued by ana1^{715-1729.Ubi.GFP}/ana1^1-706.Ubi

(Nagy et al., 2025)

ana1^null is not rescued by ana1^1-706.Ubi/ana1^975-1729

(Nagy et al., 2025)

ana1^null is not rescued by ana1^1-706.Ubi/ana1^715-1729

(Nagy et al., 2025)

ana1^null is not rescued by ana1^1-706.Ubi/ana1^820-1729

(Nagy et al., 2025)

ana1^null is not rescued by ana1^{1-935.Ubi.mRFP1}

(Nagy et al., 2025)

ana1^null is not rescued by ana1^{1-935.Ubi.mRFP1}/ana1^975-1729

(Nagy et al., 2025)

ana1^null is not rescued by ana1^1-935.mRFP1

(Nagy et al., 2025)

ana1^null is not rescued by ana1^1-935.mRFP1/ana1^975-1729

(Nagy et al., 2025)

ana1^null is not rescued by ana1^{545-1729.Ubi.GFP}

(Nagy et al., 2025)

ana1^null is not rescued by ana1^{715-1729.Ubi.GFP}

(Nagy et al., 2025)

ana1^null is not rescued by ana1^715-1729

(Nagy et al., 2025)

ana1^null is not rescued by ana1^820-1729

(Nagy et al., 2025)

ana1^null is not rescued by ana1^975-1729

(Nagy et al., 2025)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ana1^null

(Nagy et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (1)

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