FB2026_02 , released June 18, 2026
Allele: Dmel\Poc1k245
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General Information
Symbol
Dmel\Poc1k245
Species
D. melanogaster
Name
FlyBase ID
FBal0245280
Feature type
allele
Associated gene
Dmel\Poc1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Blachon et al., 2009)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide numbering relative to ATG.

    (Blachon et al., 2009)

    Nucleotide substitution: G880A.

    (Blachon et al., 2009)

    Eliminates the predicted 5' intron splice site, predicted to result in a frameshift after the first exon and generating a truncated protein consisting of only the WD beta-propeller structure.

    (Blachon et al., 2009)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:13,388,993..13,388,993 [-]
    Nucleotide change:

    G13388993A

    Reported nucleotide change:

    G880A

    Comment:

    G to A mutation in the splice donor site.

    (Blachon et al., 2009)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous Poc1k245 adults display morphological defects in sperm centrioles (shorter giant centriole compared to controls) but their locomotor behavior appears unaffected (suggesting sensory cilia function is not perturbed).

        (Khire et al., 2016)

        Heterozygotes, homozygotes and hemizygotes (with Df(3L)Ly) have shorter centrioles in spermatocytes compared to controls. Homozygotes have impaired formation of the proximal centriole-like structure.

        (Blachon et al., 2009)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Poc1k245
        k245
        (Blachon et al., 2009)
        poc1k245
        (Khire et al., 2016, Blachon et al., 2009)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)