FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\parkJF01200
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General Information
Symbol
Dmel\parkJF01200
Species
D. melanogaster
Name
FlyBase ID
FBal0245492
Feature type
allele
Associated gene
Dmel\park
Associated Insertion(s)
Carried in Construct
P{TRiP.JF01200}
Also Known As
UAS-parkinRNAi, UAS-parkin RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
in vitro construct
(Ni et al., 2008)
Progenitor genotype
Carried in construct
P{TRiP.JF01200}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF01200
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  amyotrophic lateral sclerosis
      modeled by Hsap\TAF15UAS.cCa
      (Kim et al., 2019)
      exacerbates  carcinoma
      modeled by scribHMS01490
      (Yadav and Srikrishna, 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing parkJF01200 under the control of Scer\GAL4Cg.PA leads to mitochondrial defects in the third instar larval fat body, including enlarged, fragmented and/or clustered mitochondria (as assessed by MitoGFP).

      (Zhou et al., 2019)

      Folic acid supplementation to flies expressing parkJF01200 under the control of either Scer\GAL4ple.PF (dopaminergic neurons) or Scer\GAL4Ddc.PL (serotonergic neurons) alleviates the reduced average life span and defects in climbing ability. Levels of oxidative stress are reduced.

      Levels of Zinc are lower in flies expressing parkJF01200 under the control of either Scer\GAL4ple.PF (dopaminergic neurons) or Scer\GAL4Ddc.PL (serotonergic neurons) are reduced compared to controls. This reduction is partially suppressed by folic acid supplementation. The reduced number of metabolically active cells, reduced ATP levels and defects in mitochondrial biogenesis are also improved by folic acid.

      (Srivastav et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4Mef2.PR/parkJF01200 is a non-suppressor of mitochondrion | adult stage phenotype of Pink1B9

      (Ham et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      parkJF01200
      Name Synonyms
      Secondary FlyBase IDs
        References (13)