FB2026_02 , released June 18, 2026
Allele: Hsap\PANK4UAS.cWa
Open Close
General Information
Symbol
Hsap\PANK4UAS.cWa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Wu
FlyBase ID
FBal0246218
Feature type
allele
Associated gene
Hsap\PANK4
Associated Insertion(s)
Carried in Construct
P{UAS-PANK4.W}
Key Links
Transgenic product class
wild_type
(Wu et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wu et al., 2009)
Mutagen
in vitro construct
(Wu et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-PANK4.W}
Cytology
Description

UAS regulatory sequences drive expression of Hsap\PANK4.

(Wu et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\PANK4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  pantothenate kinase-associated neurodegeneration
      modeled by fbl1
      (Wu et al., 2009)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Hsap\PANK4UAS.cWa/Scer\GAL4Act.PU is a non-suppressor of male sterile phenotype of fbl1

      (Wu et al., 2009)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\PANK4Scer\UAS.cWa under the control of Scer\GAL4Act.PU in a fbl1 mutant background dramatically increases the eclosion rate of fbl1 mutant flies, and the lifespan of these animals is much increased. Flies display normal climbing behaviour when young, however the climbing ability of these animals is less than 50% of control levels at 30 days. Female fertility is restored in these animals but male sterility is not restored.

      (Wu et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\PANK4Scer\UAS.cWa
      Hsap\PANK4UAS.cWa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Wu
      Secondary FlyBase IDs
        References (1)