FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SPARCUAS.cMa
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General Information
Symbol
Dmel\SPARCUAS.cMa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Martinek
FlyBase ID
FBal0246230
Feature type
allele
Associated gene
Dmel\SPARC
Associated Insertion(s)
Carried in Construct
P{UAS-SPARC.M}
Also Known As
UAS-SPARC
Key Links
Transgenic product class
cDNA
(Martinek et al., 2008)
wild_type
(Martinek et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Martinek et al., 2008)
wild_type
(Martinek et al., 2008)
Mutagen
in vitro construct
(Martinek et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-SPARC.M}
Cytology
Description

UASt regulatory sequences drive expression of full-length SPARC cDNA (915bp).

(Martinek et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
SPARC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  cardiomyopathy
      CEA
      (Vaughan et al., 2018)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      SPARCUAS.cMa/Scer\GAL4Cg.PA rescues SPARCnm136

      (Shahab et al., 2015)
      Comments

      Scer\GAL4Cg.PA-mediated expression of BM-40-SPARCScer\UAS.cMa rescues SPARCnm136 mutants to adulthood.

      (Shahab et al., 2015)

      Expression of BM-40-SPARCScer\UAS.cMa in the haemocytes under the control of Scer\GAL4gcm-rA87.P or Scer\GAL4srp.Hemo fails to rescue embryonic lethality of BM-40-SPARCnm136 embryos (co-expressing His2AvT:Avic\GFP-S65T to rescue defects due to disruption of His2Av). Ventral cuticle morphology is restored and tracheal defects are suppressed in these embryos.

      Expression of BM-40-SPARCScer\UAS.cMa in neural tissues under the control of Scer\GAL4sca-109-68 fails to rescue the mutant phenotype of BM-40-SPARCnm136 embryos (co-expressing His2AvT:Avic\GFP-S65T to rescue defects due to disruption of His2Av).

      (Martinek et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      BM-40-SPARCScer\UAS.cMa
      SPARCScer\UAS.cMa
      SPARCUAS.cMa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Martinek
      Secondary FlyBase IDs
        References (3)