FlyBase Allele Report: Dmel\Wnt4[P23]

General Information

Symbol

Dmel\Wnt4^P23

Species

D. melanogaster

Name

FlyBase ID

FBal0246428

Feature type

allele

Associated gene

Dmel\Wnt4

Associated Insertion(s)

Carried in Construct

Also Known As

DWnt4^P23

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Sato et al., 2006)

Progenitor genotype

l(2)SH0553^SH0553

(Sato et al., 2006)

Cytology

Description

Imprecise excision of P{lacW}l(2)SH0553^SH0553 removes most of the first exon of Wnt4 (a 1.3kb section starting 2bp upstream of the transcription start site and containing the translation start site is deleted).

(Sato et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Sato et al., 2006)

abnormal neuroanatomy (with Wnt4^EMS23)

(Sato et al., 2006)

abnormal neuroanatomy | P-stage (with Wnt4^EMS23)

(Han et al., 2020)

Phenotype Manifest In

eye photoreceptor cell

(Sato et al., 2006)

eye photoreceptor cell (with Wnt4^EMS23)

(Sato et al., 2006)

lamina

(Sato et al., 2006)

lamina (with Wnt4^EMS23)

(Sato et al., 2006)

medulla | P-stage (with Wnt4^EMS23)

(Han et al., 2020)

medulla intrinsic neuron Mi1 | P-stage (with Wnt4^EMS23)

(Han et al., 2020)

neuron

(Sato et al., 2006)

neuron (with Wnt4^EMS23)

(Sato et al., 2006)

photoreceptor cell R8 | P-stage (with Wnt4^EMS23)

(Han et al., 2020)

Detailed Description

Statement

Reference

Ventral-to-dorsal misroutings are found in 28.6% of Wnt4^P23 homozygotes, with no animals showing a dorsal-to-ventral phenotype. In Wnt4^P23/Wnt4^EMS23 trans-heterozygotes the ventral-to-dorsal phenotype is weaker, with rare cases of a dorsal-to-ventral phenotype.

Wnt4^P23 heterozygotes do not show any R axon misrouting defects.

(Sato et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Wnt4^P23 has abnormal neuroanatomy phenotype, enhanceable by hep^r75

(Sato et al., 2006)

Enhancer of

Statement

Reference

Wnt4[+]/Wnt4^P23 is an enhancer of abnormal neuroanatomy phenotype of hep^r75

(Sato et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

Wnt4^P23 has neuron phenotype, enhanceable by hep^r75

(Sato et al., 2006)

Wnt4^P23 has lamina phenotype, enhanceable by hep^r75

(Sato et al., 2006)

Wnt4^P23 has eye photoreceptor cell phenotype, enhanceable by hep^r75

(Sato et al., 2006)

Wnt4^P23 has embryonic/larval optic stalk phenotype, enhanceable by hep^r75

(Sato et al., 2006)

Enhancer of

Statement

Reference

Wnt4[+]/Wnt4^P23 is an enhancer of neuron phenotype of hep^r75

(Sato et al., 2006)

Wnt4[+]/Wnt4^P23 is an enhancer of lamina phenotype of hep^r75

(Sato et al., 2006)

Wnt4[+]/Wnt4^P23 is an enhancer of eye photoreceptor cell phenotype of hep^r75

(Sato et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Wnt4^EMS23/Wnt4^P23 does not enhance the neuronal targeting defect seen in Df(3R)Tl-X/Df(3R)ro-XB3 embryos, in which the nerve terminals synapsed to muscle M12 are greatly reduced and the nerve terminals synapsed to muscle M13 are expanded compared to controls.

(Inaki et al., 2010)

A Wnt4^P23/+ background enhances the hep^r75 R axon misrouting phenotype.

A hep^r75 background enhances the Wnt4^P23/+ R axon misrouting phenotype.

(Sato et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

DWnt4^P23

(Han et al., 2020, Sato et al., 2006)

Wnt4^P23

(Inaki et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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