FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Sesn3F6
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General Information
Symbol
Dmel\Sesn3F6
Species
D. melanogaster
Name
FlyBase ID
FBal0246586
Feature type
allele
Associated gene
Dmel\Sesn
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Lee et al., 2010)
Mutagen
Delta2-3 transposase
(Lee et al., 2010)
Progenitor genotype
P{XP}Sesnd04539
(Lee et al., 2010)
Cytology
Description

Deletion that removes part of the Sesn 5'UTR. Generated by imprecise excision of P{XP}Sesnd04539.

(Lee et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:23,713,238..23,717,156 [+]
Comment:

Deletion in the 5' UTR of Sesn resulting from the imprecise excision of P{XP}Sesnd04539 reported at 2R:19600761..19604679 in R5 coordinates.

(Lee et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      20-day old Sesn3F6/Df(2R)Sesn-8A11 mutant flies show degeneration of thoracic muscles with loss of sarcomeric structure, including discontinued Z discs, disappearance of M bands, scrambled actomyosin arrays, and diffused sarcomere boundaries. Such defects are only partially observed in very old wild-type flies (~90 days).

      Despite its normal appearance, muscle from 5-day-old Sesn3F6/Df(2R)Sesn-8A11 mutant flies exhibit mitochondrial abnormalities, including rounded shape, occasional enlargement, and disorganisation of cistae, which are also observed in 20-day old mutants.

      (Lee et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Expression of SesnC86S.UAS.Tag:MYC via Scer\GAL4hs.PB in Sesn3F6/Df(2R)Sesn-8A11 mutants prevents muscle degradation.

      (Lee et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sesn3F6
      dSesn3F6
      (Lee et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)