FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\SLC12A5UAS.cHa
Open Close
General Information
Symbol
Hsap\SLC12A5UAS.cHa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Hekmat-Scafe
FlyBase ID
FBal0246599
Feature type
allele
Associated gene
Hsap\SLC12A5
Associated Insertion(s)
Carried in Construct
P{UAS-hKCC2.H}
Key Links
Transgenic product class
cDNA
(Hekmat-Scafe et al., 2010)
wild_type
(Hekmat-Scafe et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Hekmat-Scafe et al., 2010)
wild_type
(Hekmat-Scafe et al., 2010)
Mutagen
in vitro construct
(Hekmat-Scafe et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-hKCC2.H}
Cytology
Description

UASt regulatory sequences drive expression of a 3.4 kb Hsap\SLC12A5 cDNA fragment.

(Hekmat-Scafe et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\SLC12A5
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  epilepsy
      modeled by kccDHS1
      (Hekmat-Scafe et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Hsap\SLC12A5UAS.cHa/Scer\GAL4c739 is a suppressor of paralytic | recessive phenotype of kccDHS1

      (Hekmat-Scafe et al., 2010)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of two copies of Hsap\SLC12A5Scer\UAS.cHa driven by two copies of Scer\GAL4c739 results in an almost complete rescue of the bang-sensitive paralytic phenotype of homozygous kccDHS1 mutants. Electrophysiology shows that Hsap\SLC12A5Scer\UAS.cHa expression raises the seizure threshold of kccDHS1 mutant flies.

      (Hekmat-Scafe et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\SLC12A5Scer\UAS.cHa
      Hsap\SLC12A5UAS.cHa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Hekmat-Scafe
      Secondary FlyBase IDs
        References (1)