FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Art150
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General Information
Symbol
Dmel\Art150
Species
D. melanogaster
Name
FlyBase ID
FBal0246608
Feature type
allele
Associated gene
Dmel\Art1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Brückner, 2013.7.16)
Mutagen
Delta2-3 transposase
(Kimura et al., 2008)
Progenitor genotype
P{SUPor-P}Art1KG09631
(Kimura et al., 2008)
Cytology
Description

PCR analysis confirms the lesion described by Kimura et al., 2008 (FBrf0204948).

(Brückner, 2013.7.16)

Imprecise excision of the progenitor insertion has resulted in a 0.8kb deletion extending from the 5'UTR and removing part of the coding region of Art1.

(Kimura et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Among the ~10% of homozygous Art150 mutants that survive to adulthood, one third show an incomplete wing posterior crossvein (PCV).

      As a caveat to the above experiments, the PCV phenotype and lethality are not seen in genetic combination of Art150 with the deficiencies Df(3R)Exel6159, Df(3R)Exel7305, Df(3R)ED5495, Df(3R)BSC479 or Df(3R)BSC529 that are reported to delete the Art1 locus.

      (Brückner, 2013.7.16)

      Most homozygotes die at the pupal stage and those homozygotes that reach the adult stage take 4 days longer to complete the pupal stage compared to heterozygous siblings.

      (Kimura et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Art150 has visible phenotype, enhanceable by dpps11

      (Brückner, 2013.7.16)
      Phenotype Manifest In
      Other
      Statement
      Reference

      Art150/Art1[+], dpps11 has wing vein phenotype

      (Brückner, 2013.7.16)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Combining homozygous Art150 with heterozygous dpps11 results in the shortening of the fifth longitudinal vein L5 in almost all flies, a venation defect that is not seen in homozygous Art150 or dpps11 heterozygotes alone.

      (Brückner, 2013.7.16)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Art150
      DART150
      (Brückner, 2013.7.16)
      dart150
      (Kimura et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)