FB2026_02 , released June 18, 2026
Allele: Dmel\MerB2
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General Information
Symbol
Dmel\MerB2
Species
D. melanogaster
Name
FlyBase ID
FBal0246635
Feature type
allele
Associated gene
Dmel\Mer
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Pellock et al., 2007)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T.

(Pellock et al., 2007)

Amino acid replacement: Q170term.

(Pellock et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:19,692,450..19,692,450 [-]
Nucleotide change:

C19692450T

Reported nucleotide change:

C?T

Amino acid change:

Q170term | Mer-PA; Q170term | Mer-PB

Reported amino acid change:

Q170term

(Pellock et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      MerB2 mosaic eyes are similar in shape and patterning to control mosaic eyes. Overgrown MerB2 mosaic eyes contain significantly more ommatidia than control eyes.

      Third instar larval eye discs, antennal discs, and wing discs of MerB2 hemizygotes are very similar in size to those from control larvae. The normal complement of differentiated photoreceptors is observed in MerB2 mutant eye disc tissue.

      Eyes comprised almost exclusively of MerB2 mutant cells are overgrown relative to control eyes.

      MerB2 mutant tissue in pupal eye discs contain a large number of supernumerary interommatidial cells, but have a mostly regular hexagonal lattice.

      (Pellock et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of BacA\p35GMR.PH in MerB2 mutant eye tissue results in large numbers of supernumerary interommatidial bristles.

      (Pellock et al., 2007)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MerB2
      merB2
      (Pellock et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)